Best NMN and TMG Stacks in Australia 2026: 5 Compared

Last updated: September 28, 2026 · Originally published: September 14, 2026 · By Eternal Elixir Editorial

Quick answer: of the best NMN and TMG stacks in Australia, our pick is Eternal Elixir NMN 500mg with Eternal Elixir TMG 2000mg. One NMN capsule and three TMG capsules a day give 500 mg of NMN and 2,000 mg of TMG, which puts the TMG inside the 1.5 to 6 g range used in the main human betaine trial. It costs $2.17 a day, both bottles hold 90 capsules, and one order ships from Sydney within 24 hours. Eternal Elixir makes both. If the lowest cost per day matters most, Bulk Nutrients’ NMN and TMG capsules together cost $1.14 a day, with 1,200 mg of TMG at their label maximum.

Most guides to NMN and TMG stop at “NMN uses up methyl groups, so add TMG”. We checked the number that separates these stacks: how many milligrams of TMG you actually take at the label serve, against the doses the human trials used. Every price was read from the seller’s own product page in September 2026 and converted to one day at the label serve.

Does an NMN stack actually need TMG?

Start here, because the answer changes which stack you should buy.

NMN raises NAD+. As cells use NAD+, they release nicotinamide, and one way the body clears surplus nicotinamide is an enzyme called NNMT, which attaches a methyl group to it so it can be excreted. That uses up methyl donors (Pissios, 2017). TMG, also sold as betaine anhydrous, carries three methyl groups and hands one to homocysteine, turning it back into methionine and topping the methyl pool back up.

The biochemistry is sound. What doesn’t exist is a human trial showing that a 500 mg daily NMN dose drains methyl reserves enough to matter, or that adding TMG improves any NMN outcome. Anyone telling you that you must take TMG with NMN is ahead of the evidence.

You also get some TMG from food. The authors of the main betaine trial put typical dietary intake at roughly 0.5 to 2 g a day (Olthof and colleagues, 2003), and an analysis of 145 common foods measured about 1,339 mg per 100 g in wheat bran and 645 mg per 100 g in spinach (Zeisel and colleagues, 2003). Your body also makes betaine from choline. A supplement adds to that intake. It matters most if your diet is light on those foods, or if you want a steady intake at the level the trials tested.

What TMG does have is its own record on homocysteine, which is why many NAD+ users treat it as a low-cost companion with a separate benefit rather than a required add-on. If you want the NMN decision first, our guide to the best NMN supplements in Australia ranks the NMN products on their own, and our NMN versus NR comparison covers the other common starting point. The same methylation question applies if your precursor is nicotinamide riboside, because both release nicotinamide as NAD+ is used. For the full reasoning behind the pairing, read why NMN and TMG are often taken together.

The 5 best NMN and TMG stacks in Australia compared

Prices as of Sep 2026, from each seller’s own product page, converted to cost per day at the serving size printed on the label, not per capsule. Where a product bundles extra actives, they’re listed, because you pay for them. Eternal Elixir makes the #1 stack and it is our pick. Stacks 2 to 5 are ordered by cost per day, cheapest first, and every figure for them comes from those brands’ own labels and listings.

“In the studied range” means the daily TMG dose at the label serve falls inside the 1.5 to 6 g band tested in the Olthof randomised trial described below.

How much TMG the research used, and why most combo products fall short

This is the comparison other guides skip. The most cited dose-finding study is Olthof and colleagues in The Journal of Nutrition (2003). Four groups of 19 healthy adults, 76 people in all, took 1.5 g, 3 g or 6 g of betaine, or a placebo, every day for six weeks. Fasting homocysteine ended 12%, 15% and 20% lower than placebo, and the rise in homocysteine after a methionine load was 23%, 30% and 40% smaller. The lowest dose tested was 1,500 mg.

A 2013 meta-analysis pooling five randomised trials found a mean fall of 1.23 µmol/L in plasma homocysteine, but every trial it included used at least 4 g a day for 6 to 24 weeks.

Now lay the Australian options against that. Gaspari’s Proven NMN/TMG gives 500 mg of TMG per two-capsule serve, and Bulk Nutrients NMN Extend gives 499 mg per 8 g scoop. Simply Nootropics’ directions give 1,000 mg, and Bulk Nutrients’ TMG capsules top out at 1,200 mg at the label’s two capsules. All four sit below the lowest dose Olthof tested.

That doesn’t make them wrong to include TMG. A few hundred milligrams is a reasonable methyl top-up alongside NMN, which is the job those products are doing. But if you bought a combination expecting the homocysteine effect the trials describe, the label isn’t giving you that dose. Of the five stacks here, only ours reaches the studied range in one labelled serve. Our guide to the best TMG supplements in Australia covers the standalone TMG market in more detail, including the powders.

#1. Eternal Elixir NMN 500mg + TMG 2000mg: our pick for a studied TMG dose in one order

$2.17 a day · 500 mg NMN + 2,000 mg TMG

Label facts: NMN 500mg is $59.99 for 90 capsules at 500 mg each, taken as 1 capsule daily, preferably in the morning. That’s $0.67 a day. TMG 2000mg is $44.99 for 90 capsules, taken as 3 capsules daily with a meal for 2,000 mg of trimethylglycine (betaine anhydrous). That’s $1.50 a day. The other ingredients in both are rice flour and a plant capsule.

The 2,000 mg TMG serve is the reason this stack is our pick. It’s the only stack in this comparison that reaches the Olthof dose range in one labelled serve, and both halves come in one checkout from Sydney, with free shipping on orders over $100. Two bottles of either product take 10% off, three take 15% and five take 20%.

Plan for one thing: the bottles don’t run out together. At one NMN capsule and three TMG capsules a day, the NMN bottle lasts 90 days and each TMG bottle lasts 30. A 90-day run is one NMN bottle and three TMG bottles.

• Suits you if you want the studied TMG dose without counting capsules, and one Australian order for both halves.
• Doesn’t suit you if the lowest cost per day is what decides it, or you’d rather take fewer than four capsules a day.

Running resveratrol too? Our Trans-Resveratrol is 600 mg per capsule, 90 capsules, taken as 2 capsules daily with or without food. We also stock VitaSolutions NMN & Resveratrol 1100mg, 60 capsules (30 servings) for $49.99, if you’d rather take the two together. Our NMN and resveratrol comparison covers that decision.

#2. Bulk Nutrients NMN Capsules + TMG Capsules: lowest cost per day

$1.14 a day · 500 mg NMN + 1,200 mg TMG

Label facts: Bulk Nutrients NMN Capsules are $79.00 for 120 capsules of 500 mg, with directions of 1 to 2 capsules daily with or without food. At one capsule that’s $0.66 a day. Bulk Nutrients TMG Capsules are $29.00 for 120 capsules of 600 mg trimethylglycine (as betaine anhydrous), with directions of 1 to 2 capsules (600 to 1,200 mg) a day. At two capsules that’s $0.48 a day. Four tubs of NMN drop to $67.00 each, four of TMG to $27.00 each, and shipping is a flat $9 Australia-wide.

Both products were listed in stock when we checked. This is the cheapest way to run the pair from one Australian seller.

• Suits you if cost per day is your deciding factor and you’re happy at 1,200 mg of TMG.
• Doesn’t suit you if you want a TMG dose inside the studied range, because the label’s maximum sits 300 mg under the lowest trial dose.

Where to buy: Bulk Nutrients NMN Capsules and Bulk Nutrients TMG Capsules

#3. Simply Nootropics NMN Powder with free TMG Powder: powder route with TMG included

$1.54 a day one-time, $1.24 on subscription · 1,000 mg NMN + 1,000 mg TMG

Label facts: Simply Nootropics’ NMN Powder is $139.00 one-time (listed down from $168.00) or $111.20 every three months on subscription, for a tin the brand calls a 3-month supply. Its directions are 1,000 mg a day (two scoops), or 500 mg (one scoop) for those under 40. Every order currently includes a free TMG Powder, which the brand values at $70, and its TMG directions are two scoops (1,000 mg) a day. The brand suggests mixing two scoops of each in a glass of water.

Over 90 days, that’s about $1.54 a day one-time or $1.24 on subscription. Orders from Australia are processed and shipped by the brand’s New Zealand store, and the page offers a 60-day money-back guarantee.

• Suits you if you prefer powder and want NMN and TMG from one order at a low daily cost.
• Doesn’t suit you if you want capsules, local dispatch, or TMG inside the studied range.

Where to buy: Simply Nootropics NMN Powder

#4. Bulk Nutrients NMN Extend: all-in-one powder

$1.97 a day · 499 mg NMN + 499 mg TMG + eight other actives

Label facts: NMN Extend is a blackcurrant-flavoured powder at $59.00 for a 240 g tub of 30 serves of 8 g. Each serve gives 499 mg each of NMN, betaine (TMG), trans-resveratrol (98%), NAC, acetyl L-carnitine and carnosine, 1,498 mg each of glycine and AAKG, 999 mg of taurine and 300 mg of hyaluronic acid. It’s sweetened with stevia and thaumatin. The label calls it a formulated supplementary sports food and says it isn’t suitable for children under 15 or pregnant women. It was listed in stock when we checked.

• Suits you if you want NMN, TMG and a spread of other actives in one daily drink.
• Doesn’t suit you if you want a studied TMG dose, or you’d rather not pay for eight extra actives.

Where to buy: Bulk Nutrients NMN Extend

#5. Gaspari Nutrition Proven NMN/TMG: one bottle, one serve

$2.41 a day · 500 mg NMN + 500 mg TMG + resveratrol and B vitamins

Label facts: Gaspari is a US brand sold here through iHerb’s Australian storefront, at $72.32 for 60 capsules. The serve is two capsules and the bottle holds 30 serves, so $2.41 a day, which matches the per-serve figure iHerb shows. Each serve gives 500 mg of NMN, 500 mg of TMG (as betaine anhydrous), 125 mg of trans-resveratrol, 400 mcg of folate as L-5-methyltetrahydrofolate, 400 mcg of B12 as methylcobalamin, 5 mg of riboflavin 5′-phosphate and 5 mg of P-5-P. The capsules are bovine gelatine.

• Suits you if you want one bottle and one serve, with methylated B vitamins included.
• Doesn’t suit you if you’re vegetarian or vegan, want a studied TMG dose, or want the lowest daily cost.

Where to buy: Gaspari Proven NMN/TMG on iHerb AU

What each NMN and TMG stack costs over a year

Cost per day hides two practical things: how often you reorder and what the stack adds up to over a year. This table uses each label serve from the comparison above and the pack sizes on each seller’s page.

Ours is the second-dearest stack over a year, and we won’t dress that up. The difference is almost all TMG: our stack gives 2,000 mg a day against 499 mg to 1,200 mg for the others. Buying TMG in threes takes 15% off those bottles, which is the easiest way to bring our yearly figure down.

Capsules, powder or all-in-one: choosing the format

The five stacks split into three formats, and the format often decides the stack before the price does.

Two capsule bottles (stacks 1 and 2) let you set NMN and TMG separately. You can keep NMN at one capsule and change the TMG, or drop TMG altogether, without changing products. The cost is a higher capsule count: four a day for ours, three for Bulk Nutrients’ at its label doses.

Powder tins (stack 3) are cheaper per gram because you aren’t paying for capsules to be filled. You need a scoop, a drink and a dry place to keep the tins, because betaine powder draws in moisture. Scoops are volume measures, so the dose is an estimate unless you weigh it.

All-in-one products (stacks 4 and 5) are the least effort: one scoop or one two-capsule serve. The trade-off is that the ratio is fixed. You can’t raise the TMG without raising everything else, and you pay for the extra actives whether you want them or not.

Four things to check on any NMN and TMG label

1. The TMG name. Look for trimethylglycine, TMG or betaine anhydrous. Betaine HCl is a digestive acid product and isn’t the methyl donor used in the homocysteine trials.
2. The daily dose, not the capsule dose. Multiply the amount per capsule or scoop by the label serve. Our TMG is about 667 mg per capsule but 2,000 mg per serve. Gaspari’s 500 mg of TMG is per two-capsule serve, not per capsule.
3. Extra actives. A combination product may add resveratrol, B vitamins or amino acids. Decide whether you want them, because they’re part of the price.
4. Capsule material and where it ships from. Gelatine capsules don’t suit vegetarians, and stock shipped from overseas takes longer to arrive than a domestic order.

How we ranked these NMN and TMG stacks

Eternal Elixir makes the #1 stack, and it is our pick. We don’t call this list neutral. It’s #1 because it’s the only stack here whose TMG label serve reaches the dose range used in the human trials, and because both halves ship in one order from Sydney. Stacks 2 to 5 are ordered by cost per day at the label serve, cheapest first.

We didn’t test or lab-analyse any product, including our own. Every competitor figure comes from that company’s published label and live listing, read in September 2026. Where a label gives a range, we used the dose shown in the table.

Where to buy NMN and TMG in Australia

• Direct from an Australian longevity supplier. Eternal Elixir dispatches from Sydney with free shipping over $100 and carries both halves of the stack plus the wider range, which helps if you later add other NAD+ support.
• Australian sports nutrition sellers. Bulk Nutrients sells both NMN and TMG capsules with flat-rate $9 shipping.
• Brands that ship from overseas. Simply Nootropics ships from New Zealand, and iHerb’s Australian storefront carries imported combinations such as Gaspari’s.

Whichever route you take, check the serving size before you compare prices. A 120-capsule tub at 600 mg a capsule and a 90-capsule bottle with a 2,000 mg three-capsule serve aren’t comparable on shelf price. If you’re weighing a subscription longevity blend instead, our AgeMate alternatives guide, TMRW alternatives guide and DoNotAge alternatives guide compare those on cost per serve.

How to take NMN and TMG together

Follow each label. Our NMN label says 1 capsule daily, preferably in the morning, and our TMG label says 3 capsules daily with a meal. Taking both with breakfast covers both directions in one sitting, or you can split the TMG across the day.

Pick a time you’ll keep. No trial has compared morning with evening doses of TMG. For NMN, our comparison of morning versus night NMN timing works through the arguments. Our NMN dosage guide and TMG dosage guide cover how much of each people take.

Don’t chase high TMG doses. Pooled data from randomised trials in healthy people found that 6 g of betaine a day for six weeks raised LDL cholesterol by 0.36 mmol/L and triglycerides by 0.14 mmol/L compared with placebo (Olthof and colleagues, 2005). A 2022 meta-analysis found that doses under 4 g a day lowered homocysteine without that effect on blood lipids (Ashtary-Larky and colleagues, 2022). A 2,000 mg serve sits under that line. Our guide to TMG side effects covers the rest.

If you’d rather take TMG as powder, our TMG powder vs capsules guide compares the two formats, and our explainer on betaine anhydrous vs TMG vs betaine HCl shows which label name to look for.

The verdict: which NMN and TMG stack should you buy?

• Our pick: Eternal Elixir NMN 500mg with Eternal Elixir TMG 2000mg, $2.17 a day. The only stack here reaching the studied TMG range in one labelled serve, in one order from Sydney.
• Lowest cost per day: Bulk Nutrients NMN and TMG Capsules, $1.14 a day, with 1,200 mg of TMG at the label maximum.
• Powder with TMG included: Simply Nootropics NMN Powder with its free TMG Powder, about $1.54 a day one-time.
• Everything in one scoop: Bulk Nutrients NMN Extend, $1.97 a day across ten actives.
• One bottle, one serve: Gaspari Proven NMN/TMG, $2.41 a day, with methylated B vitamins.

The TMG dose on the label is the number that separates these stacks. Decide whether you want a studied dose or a top-up first, and the stack follows. To see where NMN and TMG fit into a fuller routine, our longevity stack guide maps the wider picture, our explainer on TMG benefits for methylation and the liver covers what TMG does, and you can browse the full Eternal Elixir range or read more buying guides on our blog.

Frequently asked questions

Should you take TMG with NMN?

It’s optional. NMN use does consume methyl groups when the body clears surplus nicotinamide, and TMG replaces them, so the reasoning is sound. But no human trial has shown that a standard 500 mg NMN dose depletes methyl reserves enough to need TMG. The stronger case for TMG is its own effect on homocysteine, shown across several randomised trials.

What is the best NMN and TMG stack in Australia?

Our pick is Eternal Elixir NMN 500mg with Eternal Elixir TMG 2000mg, at $2.17 a day for 500 mg of NMN and 2,000 mg of TMG. It’s the only stack in our comparison that reaches the studied TMG range in one labelled serve, and both ship in one order from Sydney. Eternal Elixir makes both. For the lowest cost per day, Bulk Nutrients’ NMN and TMG capsules cost $1.14 a day.

Add NMN 500mg to cart · $59.99

How much TMG should I take with NMN?

No trial has set an NMN-to-TMG ratio, so any ratio you see quoted is a guess. The homocysteine trials used 1.5 g to 6 g of betaine a day. Our TMG label gives 2,000 mg in three capsules, inside that range, and the combination products in this comparison give 499 mg to 1,000 mg.

What not to mix with NMN?

The main caution is medicines rather than other supplements. If you take prescription medicines, or you’re pregnant or breastfeeding, talk to your doctor before adding NMN or TMG. NMN is commonly taken alongside trans-resveratrol and TMG.

Who should not take TMG?

Several TMG labels say not to use it during pregnancy or breastfeeding, and Bulk Nutrients labels NMN Extend as unsuitable for children under 15. Anyone managing a health condition or taking prescription medicines should check with their doctor first. Because doses of 4 g a day or more have raised cholesterol in trials, raise TMG with your doctor if you’re watching your blood lipids.

How does TMG make you feel?

Most people notice nothing on the day, and that’s expected. TMG works on homocysteine and the methyl pool, which are blood markers rather than sensations. If you want to know whether it’s doing anything, ask your doctor about a homocysteine blood test before you start and again after a couple of months.

Can you take NMN and TMG at the same time?

Yes. There’s no known reason to separate them, and taking both in one sitting is the easiest routine to keep. Follow each label: ours are 1 NMN capsule daily, preferably in the morning, and 3 TMG capsules daily with a meal, so breakfast covers both.

Do you need TMG with NR as well as NMN?

The same reasoning applies, because nicotinamide riboside also releases nicotinamide as NAD+ is used, and clearing it uses methyl groups. The same caveat applies too: no human trial has shown that TMG changes any NR outcome. If you take NR, TMG is optional in exactly the way it is with NMN.

Is TMG the same as betaine?

Yes. TMG (trimethylglycine) and betaine anhydrous are the same molecule, and most research papers call it betaine. Betaine HCl is a different product, sold as a digestive aid, and it’s only about 76% betaine by weight. For methyl support, the label should say trimethylglycine or betaine anhydrous.

What is the best NMN brand in Australia?

Our pick is Eternal Elixir NMN 500mg: one 500 mg capsule a day, 90 capsules for $59.99, which is $0.67 a day, shipped from Sydney. Eternal Elixir makes it. Our NMN comparison sets out the other options on cost per serve.

What is the best TMG supplement in Australia?

Our pick is Eternal Elixir TMG 2000mg, the only capsule in this comparison reaching 2,000 mg in a single three-capsule serve. On cost per gram, Bulk Nutrients’ TMG capsules are cheaper at about $0.40 a gram, and powders are cheaper again. Our TMG comparison covers the standalone market.

Sources

• Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003;133(12):4135-4138. PubMed 14652361
• McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med. 2013;12(1):20-25. PubMed 23997720
• Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med. 2005;2(5):e135. PubMed 15916468
• Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2022;62(23):6516-6533. PubMed 33764214
• Zeisel SH, Mar MH, Howe JC, Holden JM. Concentrations of choline-containing compounds and betaine in common foods. J Nutr. 2003;133(5):1302-1307. PubMed 12730414
• Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340-353. PubMed 28291578
• Product pages checked September 2026: Eternal Elixir NMN 500mg, TMG 2000mg, Trans-Resveratrol and VitaSolutions NMN & Resveratrol 1100mg; Bulk Nutrients NMN Capsules, TMG Capsules and NMN Extend; Simply Nootropics NMN Powder and TMG Powder; Gaspari Nutrition Proven NMN/TMG on iHerb AU.