Best NMN and TMG Stacks in Australia 2026: 5 Compared

Last updated: September 14, 2026 · By Eternal Elixir Editorial

Last updated: September 14, 2026 · By Eternal Elixir Editorial · 5 stacks compared

Every major buying guide to the best NMN and TMG stack says the same thing: NMN uses up methyl groups, so add TMG. Almost none of them check the number that decides if your TMG serve does anything at all — how many milligrams you actually swallow per day, against the doses used in the human trials. Run that check across the products Australians can buy and the gap is stark: the two ready-made NMN and TMG combination products sold here deliver 499 mg and 500 mg of TMG per serve, while the lowest dose in the best-known betaine trial was 1.5 g and the pooled meta-analysis threshold was 4 g a day.

That is the whole problem with the convenient option. This guide compares five ways to run NMN and TMG together in Australia, every price checked on the live product page on 14 September 2026, every stack normalised to one day at the label serve so the cost figures are actually comparable. The best NMN and TMG stack on cost turned out not to be a single bottle at all, and the cheapest TMG per gram is not ours.

Do you need TMG with NMN? Not necessarily. NMN metabolism consumes methyl groups, and TMG replaces them, but no large human trial has shown that standard NMN doses cause methyl depletion requiring TMG. Most Australian buyers take it as low-cost insurance.

Does the best NMN stack actually need TMG?

Start here, because the answer changes which stack you should buy.

NMN raises NAD+. As cells use NAD+, they release nicotinamide, and clearing surplus nicotinamide happens largely through methylation by the enzyme NNMT, which spends methyl groups drawn from the SAMe cycle.

TMG — trimethylglycine, also sold as betaine anhydrous — carries three methyl groups and hands one to homocysteine, recycling it back to methionine and topping the pool back up.

The biochemistry is sound and well described in the published NMN literature. What does not exist is a human trial showing that a 500 mg daily NMN dose depletes methyl reserves enough to matter, or that adding TMG improves any NMN outcome. Anyone telling you that you must take TMG with NMN is ahead of the evidence.

What TMG does have is its own independent record on homocysteine, which is why most Australian NAD+ users we see treat it as cheap insurance with a standalone benefit rather than a mandatory add-on. If you want the NMN side of the decision first, our guide to the best NMN supplements in Australia ranks the NMN products on their own merits, and the NMN versus NR comparison for Australian buyers covers how NMN compares with nicotinamide riboside as a starting point.

The same methylation question applies if your NAD+ precursor is nicotinamide riboside rather than NMN — both release nicotinamide as NAD+ is used, and both clear it the same way. TMG is the standard companion either way.

Three groups have the clearest reason to add it: people taking 1 g or more of NMN daily, people who already know they carry an MTHFR variant, and anyone whose bloods have shown raised homocysteine. For a 500 mg NMN habit, it is optional — worth taking if the cost per day sits where you want it, not a requirement.

The 5 best NMN and TMG stacks in Australia compared

Every price below was read from the live product page on 14 September 2026 and converted to cost per day at the serving size printed on that label — not per capsule, which is the figure that makes multi-capsule serves look artificially cheap. Where a product bundles extra actives, they are listed, because you are paying for them.

“Inside studied range” means the daily TMG dose falls within the 1.5–6 g band tested in the Olthof randomised trial.

Bulk Nutrients NMN Extend was listed as temporarily out of stock when we checked on 14 September 2026.

How much TMG the research actually used — and why the combo bottles fall short

This is the comparison the other guides skip, and it is the single most useful thing on this page. Here is what the published human work on betaine actually tested.

The most cited dose-finding study is Olthof and colleagues, published in The Journal of Nutrition in 2003 (PMID 14652361). Four groups of 19 healthy adults — 76 people in total — took 1.5 g, 3 g or 6 g of betaine, or placebo, every day for six weeks.

After six weeks, the rise in plasma homocysteine following a methionine load was blunted by 23%, 30% and 40% respectively across the three ascending doses. The lowest dose that did anything measurable was 1,500 mg.

A separate six-week trial by Steenge, Verhoef and Katan, also in The Journal of Nutrition, gave 6 g of betaine daily to participants with mildly raised homocysteine and confirmed the effect at that much higher dose. And a 2013 meta-analysis in the Journal of Chiropractic Medicine pooling five randomised trials found a mean fall of 1.23 µmol/L in plasma homocysteine — but every trial it included used at least 4 g a day.

Now lay the Australian products against that. Gaspari’s Proven NMN/TMG delivers 500 mg of TMG per two-capsule serve. Bulk Nutrients NMN Extend delivers 499 mg per 8 g scoop. Both sit below the lowest dose Olthof tested, and at roughly an eighth of the meta-analysis threshold.

They are not wrong to include TMG — 500 mg is a reasonable methyl top-up for a 500 mg NMN habit, which is the specific job they are doing. But if you bought a combination bottle expecting the homocysteine effect the studies describe, the label is not delivering it.

Reaching the tested range means a separate TMG product. Bulk Nutrients TMG Capsules at two capsules gives 1,200 mg; Eternal Elixir TMG 2000mg gives 2,000 mg in its three-capsule serve. Neither reaches the 4 g used in the pooled analysis, and we are not going to pretend otherwise — but only Eternal Elixir TMG 2000mg clears the 1,500 mg floor Olthof tested.

Bulk Nutrients at two capsules sits 300 mg under it, and needs a third capsule to get there. Our dedicated guide to the best TMG supplements in Australia works through the standalone TMG market in more detail, including the powders.

#1. Eternal Elixir NMN 500mg + Bulk Nutrients TMG Capsules — best cost per day

$1.15 a day · 500 mg NMN + 1,200 mg TMG

This is the stack the numbers pick, and it is a mixed one. Eternal Elixir NMN 500mg costs $59.99 for 90 capsules, one capsule per serve, which is $0.67 a day — among the lowest verified cost per 500 mg serve in Australia.

Bulk Nutrients TMG Capsules cost $29.00 for 120 capsules at 600 mg each; two capsules deliver 1,200 mg for $0.48.

Together, $1.15 a day for a substantial methyl dose alongside a full NMN serve.

Bulk Nutrients manufactures in Tasmania, its TMG capsules are vegan and gluten-free, and shipping is a flat $9 anywhere in Australia. Eternal Elixir dispatches from Sydney with free shipping over $100. Nothing about this pairing is compromised — it is simply two companies each doing one thing at a good price.

Key specs: NMN 500 mg per capsule, 90 capsules per bottle; TMG 600 mg per capsule, 120 capsules per tub. Both third-party tested by their respective manufacturers. Both vegan.

Pros:

• Cheapest complete NMN and TMG pairing in this comparison by a wide margin
• TMG at about $0.40 a gram — the cheapest per gram in this comparison
• Both halves dispatch domestically — no import wait
• The TMG tub lasts 60 days at two capsules a day

Cons:

• Two suppliers, two checkouts, two delivery charges unless you order enough
• 1,200 mg at two capsules sits 300 mg under the 1,500 mg lowest dose Olthof tested — a third capsule reaches 1,800 mg
• Reaching 2,000 mg of TMG needs three to four Bulk capsules, which erodes the price advantage
• Bulk Nutrients does not sell a standalone NMN capsule to match, so you cannot consolidate

Best for: anyone optimising purely on cost per day who does not mind ordering from two Australian sites.

#2. Eternal Elixir NMN 500mg + Eternal Elixir TMG 2000mg — best single-supplier stack

$2.17 a day · 500 mg NMN + 2,000 mg TMG

If you would rather run the whole stack from one Australian supplier and take the full dose in one go, this is the pairing.

Eternal Elixir NMN 500mg at $59.99 for 90 capsules and Eternal Elixir TMG 2000mg at $44.99 for 90 capsules come to $2.17 a day — $1.02 more than the mixed stack above, in exchange for 800 mg more TMG, one checkout, and a single three-capsule serve rather than counting out capsules to hit a target.

The 2,000 mg serve is the specific reason this stack exists. It is the only capsule product in this comparison that reaches the Olthof dose range in one labelled serve, and it does it with betaine anhydrous and nothing else — vegetable capsule, rice flour, no fillers or colours. Both products are third-party lab tested for identity and potency, and both are 90 capsules per bottle.

One thing worth planning for: the bottles do not run out together. At one NMN capsule and three TMG capsules a day, the NMN bottle lasts 90 days and the TMG bottle lasts 30. A 90-day run is one NMN bottle and three TMG bottles.

Pros:

• Only capsule stack here delivering 2,000 mg of TMG in a single serve
• One Australian supplier, one checkout, free shipping over $100, Sydney dispatch
• Third-party tested, vegan capsules, no fillers
• Slots into a wider longevity range if you later add resveratrol, spermidine or TUDCA

Cons:

• $1.02 a day dearer than stack #1
• TMG costs about $0.75 a gram against Bulk Nutrients at roughly $0.40
• Three capsules is a larger daily count than a 500 mg combo serve
• Refill cycles are out of step at 90 days versus 30

Best for: NAD+ users who want the tested TMG dose from one Australian supplier and intend to build a broader longevity stack over time.

#3. Bulk Nutrients NMN Extend — best all-in-one, stock permitting

$1.97 a day · 499 mg NMN + 499 mg TMG + eight other actives

NMN Extend is a blackcurrant-flavoured powder: $59.00 for a 240 g tub of 30 8 g serves, which is $1.97 a day.

Each serve carries 499 mg of NMN, 499 mg of TMG, 499 mg of trans-resveratrol, 499 mg of NAC, 1,498 mg each of glycine and AAKG, 999 mg of taurine, 499 mg each of acetyl L-carnitine and carnosine, and 300 mg of hyaluronic acid. Ten actives for under two dollars is real value if you wanted most of them anyway.

It is vegan, made in Tasmania, ships flat-rate $9, and holds a 4.12 average across 121 customer reviews on Bulk’s own site — reviewers consistently praise the convenience and value, with the blackcurrant flavour the recurring complaint. When we checked on 14 September 2026 the product was listed as temporarily out of stock pending a restock, so confirm availability before planning around it.

Pros:

• Ten actives in one scoop at $1.97 a day
• Australian-made, vegan, flat-rate domestic shipping
• Large, consistent review base

Cons:

• TMG at 499 mg sits below the lowest dose in the Olthof trial
• Powder, not capsules — you need water and a scale or spoon
• Was out of stock at the time of writing
• You pay for eight extra actives you may not want

Best for: people who want NMN, TMG and a spread of supporting actives in one daily drink and do not need a research-range TMG dose.

#4. Gaspari Nutrition Proven NMN/TMG — best single-bottle capsule combo

$2.41 a day · 500 mg NMN + 500 mg TMG + resveratrol and methylated B vitamins

This is the only true single-bottle NMN and TMG capsule product readily available to Australian buyers, sold through iHerb’s Australian storefront at $72.32 for 60 capsules. The label serve is two capsules and the tub holds 30 serves, so $2.41 a day — a figure iHerb prints on the listing itself.

The formula is more thoughtful than the headline pair suggests: alongside 500 mg of NMN and 500 mg of TMG it carries 125 mg of trans-resveratrol, 400 mcg of folate as L-5-methyltetrahydrofolate and 400 mcg of B12 as methylcobalamin, plus riboflavin and P-5-P. Those are the active, methylated forms, and they feed the same one-carbon cycle TMG supports — a genuinely sensible inclusion that neither Australian option matches.

Two practical caveats. The capsules are bovine gelatine, so it is not suitable if you are vegan or vegetarian. And it is imported from the United States, so delivery is slower than a domestic dispatch even with iHerb’s free shipping over $80.

Pros:

• One bottle, one two-capsule serve, nothing to measure
• Methylated folate and B12 support the same pathway as TMG
• Adds 125 mg of trans-resveratrol

Cons:

• Dearest stack in this comparison at $2.41 a day
• TMG at 500 mg is below the lowest trial dose
• Gelatine capsules — not vegan or vegetarian
• Imported, so longer delivery than the Australian options

Best for: buyers who value one bottle and one serve above cost, and who want the methylated B vitamins bundled in.

#5. Eternal Elixir NMN + Resveratrol 1100mg + TMG 2000mg — best Sinclair-style stack

$2.61 a day · 1,100 mg combined NMN and trans-resveratrol + 2,000 mg TMG

If you are already running the NMN-with-resveratrol protocol and want methyl support layered on, this is the tidiest route.

Eternal Elixir NMN + Resveratrol 1100mg is $49.99 for 90 capsules at two capsules per serve — 45 serves, $1.11 a day — and adding the TMG at $1.50 brings the total to $2.61.

It is the dearest stack here, and it should be: you are buying three actives rather than two. Whether the resveratrol earns its place is a separate argument, and we work through it in our guide to the best NMN and resveratrol combination supplements. What this pairing does well is keep a three-active routine inside one order from one Australian supplier, at five capsules a day total.

If you would rather control the ratio yourself, Eternal Elixir also sells Trans-Resveratrol 1200mg as a standalone 90-capsule bottle, which lets you dose the two independently at a higher combined cost.

Pros:

• Three actives, one supplier, one delivery
• Full 2,000 mg research-range TMG serve retained
• Cheaper than buying NMN and trans-resveratrol as separate bottles

Cons:

• Dearest stack in this comparison
• Five capsules a day
• You cannot adjust the NMN-to-resveratrol ratio

Best for: people committed to the resveratrol pairing who want methyl support without adding a third supplier.

How we ranked these NMN and TMG stacks

Eternal Elixir sells two of the products in this comparison, so the method matters. Here is exactly what we weighted and what we did not do.

• Quality and purity (30%) — ingredient form, capsule material, fillers, and whether the manufacturer holds third-party testing on that product.
• Australian availability and shipping (20%) — domestic dispatch beats import; stock status on the day of checking counts.
• Cost per day in AUD (20%) — calculated from the label’s stated serving size, never per capsule.
• Range for stacking (15%) — whether the supplier lets you consolidate a wider routine into one order.
• Reviews and reputation (15%) — publicly visible customer review volume and average on the seller’s own listing.

What we did not do: we did not test, trial or lab-analyse any competitor product.

We hold third-party Certificates of Analysis for Eternal Elixir’s own formulations and nothing else, so every competitor figure here comes from that company’s published label and live listing, read on 14 September 2026.

We have no first-hand experience of how any of these products perform in an individual, and neither does any other roundup claiming to have “tested” eight brands.

Applying that method honestly put a mixed stack at #1 and Eternal Elixir’s own pairing at #2, and identified a competitor as the cheapest TMG per gram. We left those results where they fell.

Where to buy NMN and TMG in Australia

Four routes, with the trade-offs that actually differ:

• Direct from an Australian specialist. Eternal Elixir dispatches from Sydney with free shipping over $100 and carries both halves of the stack plus the wider longevity range — useful if you intend to add other NAD+ support later.
• Australian sports nutrition retailers. Bulk Nutrients and Nutrition Warehouse carry TMG at competitive prices with flat-rate domestic shipping. Strong on TMG, thin on standalone NMN capsules.
• iHerb’s Australian storefront. The widest catalogue and the only single-bottle NMN and TMG combination, but stock is imported, so build in delivery time.
• Pharmacy chains. NMN has appeared on pharmacy shelves through house and partner brands, but standalone TMG remains rare and per-serve pricing is typically higher than online specialists.

Whichever route you take, check the serving size before you compare prices.

A 120-capsule tub at 600 mg a capsule and a 90-capsule bottle at a 2,000 mg three-capsule serve are not comparable on shelf price, and that single mismatch is responsible for most of the bad value advice in this category.

How to take NMN and TMG together

Two capsules and a glass of water is the whole protocol, but three details change how much you get out of the pairing.

Take them in the same sitting. TMG donates methyl groups that support the methylation load NMN adds. There is no advantage to splitting the two across the day, and a single daily slot is far easier to hold to over months.

Morning, with or without food. Both are water-soluble and neither depends on dietary fat for uptake. Most people settle on a morning dose because that is when the habit sticks — our comparison of morning versus night NMN timing works through the sleep and circadian arguments in detail.

Start TMG low and hold it there for a fortnight. 500 to 750 mg alongside your NMN serve is a sensible opening dose. If it sits well, step up toward the 1,500 to 2,000 mg range the trials used. Jumping straight to 2,000 mg is the most common reason people report feeling flat in the first week.

Serve sizes differ enough between these products that the label is the only reliable guide: a 600 mg capsule and a 2,000 mg three-capsule serve are not interchangeable. Our NMN dosage guide for Australia sets out the per-kilogram figures behind the common 250 mg, 500 mg and 1,000 mg serves.

Consistency beats precision here. A 500 mg NMN serve taken every morning for six months does more for you than a 1,000 mg serve taken whenever it crosses your mind.

Frequently asked questions

Should you take TMG with NMN?

Not necessarily. NMN metabolism does consume methyl groups, and TMG replaces them, so the reasoning is sound.

But no large human trial has shown that a standard 500 mg NMN dose depletes methyl reserves enough to require TMG. The stronger case for TMG is its own independent effect on homocysteine, shown across several randomised trials. Most Australian buyers take it as inexpensive insurance rather than a requirement.

Is it good to take TMG with NMN?

For people taking 1 g or more of NMN daily, those with a known MTHFR variant, or anyone with raised homocysteine on bloods, it is a reasonable addition. At 500 mg of NMN a day it is optional.

The practical question is cost: at $0.48 a day for 1,200 mg from Bulk Nutrients or $1.50 for 2,000 mg from Eternal Elixir, it is cheap enough that most people add it and stop worrying about the debate.

What not to mix with NMN?

The genuine caution is medicines rather than other supplements.

If you take anything affecting methylation or one-carbon metabolism, blood pressure medication, or you are pregnant or breastfeeding, speak to a qualified healthcare professional before adding either NMN or TMG. NMN sits comfortably alongside trans-resveratrol, TMG and most longevity supplements. Nothing here is medical advice.

Who should not take TMG?

TMG is not suitable during pregnancy or breastfeeding, and Bulk Nutrients labels its capsules as unsuitable for under-15s. Anyone managing a health condition, taking prescription medicines or preparing for surgery should check with their doctor first. People with raised blood lipids should be aware that betaine at high doses has been studied for effects on blood lipids alongside its homocysteine effect, which is worth raising with a clinician.

How does TMG make you feel?

Most people notice nothing acute, and that is expected — TMG works on homocysteine and the methyl pool, which are blood markers rather than sensations. A minority report a mild lift in mood or energy.

Some report a fishy body odour at high doses, a known effect of excess betaine metabolism that usually resolves on lowering the dose. If you are expecting a stimulant effect, TMG is not that.

How much TMG should I take with NMN?

Common practice is 500 mg to 1,500 mg daily, often matched roughly to the NMN dose. The published trials used 1.5 g to 6 g.

A serve of 2,000 mg sits at the bottom of that tested range, and 1,200 mg falls just under it. Take it with your morning NMN, or split it across the day.

What is the best NMN brand in Australia?

On verified cost per 500 mg serve the Australian market is tightly bunched at the top, with Eternal Elixir NMN 500mg at $0.67 a serve among the leaders. Our dedicated NMN comparison ranks the NMN products on their own merits rather than as part of a stack, and the top position there is not ours.

What is the best TMG supplement in Australia?

On cost per gram, Bulk Nutrients TMG Capsules at roughly $0.40 a gram are the cheapest capsule option. On dose per serve, Eternal Elixir TMG 2000mg is the only capsule reaching 2,000 mg in a single three-capsule serve.

Our best TMG supplements guide compares the standalone market including powders, which are cheaper again per gram.

The verdict: which NMN and TMG stack should you buy?

If cost per day is what decides it: Eternal Elixir NMN 500mg with Bulk Nutrients TMG Capsules, $1.15 a day for 500 mg of NMN and 1,200 mg of TMG. Two orders, two domestic dispatches, and a TMG dose inside the tested range.

If you want one supplier and the full dose: Eternal Elixir NMN 500mg with Eternal Elixir TMG 2000mg, $2.17 a day. The only capsule stack here reaching 2,000 mg of TMG in one serve, from Sydney, free over $100.

If you want everything in one scoop: Bulk Nutrients NMN Extend at $1.97 a day — excellent value across ten actives, provided you accept 499 mg of TMG and can get it in stock.

If you want one bottle and one serve: Gaspari Proven NMN/TMG at $2.41 a day, with methylated folate and B12 included. Dearest here, and imported, but the least fuss.

If you are running the resveratrol protocol: Eternal Elixir NMN + Resveratrol 1100mg with the TMG at $2.61 a day.

The thread running through all five is that the TMG dose on the label is the number that separates them, not the brand on the bottle. Both ready-made combinations deliver around 500 mg; both standalone Australian options clear 1,200 mg. Decide which of those you want first, and the stack chooses itself. If you want to see where either fits into a fuller routine, our longevity stack guide maps the wider picture, and our piece on morning versus night NMN dosing covers the timing question.

This guide is general information, not medical advice. Speak with a qualified healthcare professional before starting any supplement, particularly if you are pregnant, breastfeeding, taking prescription medicines or managing a health condition.