Last updated: September 26, 2026 · Originally published: May 14, 2026 · By Eternal Elixir Editorial
Quick Answer
Of the anti-ageing supplements for women over 40, our pick is Eternal Elixir Saffron Extract 30mg. It uses affron, the same saffron extract that improved mood and psychological symptoms in a 12-week trial of 86 women in perimenopause, at almost the same daily amount. It is 90 capsules for $49.99, one a day, which is $0.56 a day. Before any anti-ageing supplement, cover the basics most women over 40 are advised to check: vitamin D, calcium, protein, omega-3 and, for many, creatine. We don’t sell those, and we say so below.
Eternal Elixir makes five of the eight products compared here, so read this as our pick with the working shown. Competitor prices were read from each live listing on 26 September 2026.
The best supplements for women over 40 depend on what you’re trying to support. Bone and muscle need different things from mood, sleep or skin, and many of the best-evidenced supplements for women in their 40s are plain nutrients rather than anything sold as “anti-ageing”.
This guide does two jobs. First it sets out the basics and whether a multivitamin is worth it. Then it compares eight anti-ageing picks for cellular health, skin and energy that you can buy in Australia, with AUD prices, the dose in each, and what the human trials on each ingredient found. Eternal Elixir makes five of the eight, and we are plain about where a competitor fits better.
Start Here: The Basics for Women Over 40
Stanford Lifestyle Medicine’s list of the top supplements for women 40+ is a useful starting point, and it is mostly nutrients:
- Creatine, 3 to 5 grams a day, for muscle, bone and cognition, especially alongside resistance training.
- Protein, 80 to 100 grams a day in total (1.2 to 1.6 g per kg of body weight), mostly from food.
- Vitamin D3, 800 to 4,000 IU a day, with a blood test to find your level.
- Calcium, 1,000mg a day for women in their 40s, from food first.
- Omega-3 fats from oily fish or a purified fish oil.
- Fibre, 25 grams a day, preferably from food.
We don’t sell any of these. If you’re unsure where you stand, ask your GP about checking vitamin D, iron and B12, which are simple blood tests, before you buy anything. Supplements for women over 40 work best as a top-up to food and training, not a replacement.
Do Women Over 40 Need a Multivitamin?
A multivitamin is a reasonable safety net if your diet is patchy, but it is not a substitute for the basics above. Most multivitamins for females carry modest amounts of many nutrients: Swisse’s Women’s Multivitamin, for example, has 25μg of vitamin D3 (1,000 IU), 50μg of vitamin B12 and 500μg of folic acid per tablet, but only 42mg of calcium, a small fraction of daily needs. Its label also says not to use it if you are pregnant or likely to become pregnant.
So what is a good multivitamin for women over 40? Look for one tablet a day, vitamin D and B12 at useful amounts, and no nutrient you’re already getting elsewhere at a high dose. Swisse also sells Women’s 50+ and 65+ versions for women over 60 and over 70. We compare the Swisse Women’s Multivitamin in the table below as the everyday pharmacy option. Eternal Elixir doesn’t make a multivitamin.
Best Supplements for Women Over 40 in Australia 2026: Comparison Table
Prices are as of Sep 2026, read from each product listing. Cost per day uses each brand’s own serving size.
| Rank | Product | Main use | Price (AUD) | Pack | Dose per serve (label) | Cost per day | Buy |
|---|---|---|---|---|---|---|---|
| 1 | Eternal Elixir Saffron Extract 30mg (our pick) | Mood through perimenopause | $49.99 | 90 capsules | 1 capsule: affron saffron extract 30mg | $0.56 | Buy |
| 2 | Eternal Elixir NMN 500mg | Cellular energy (NAD+) | $59.99 | 90 capsules | 1 capsule: NMN 500mg | $0.67 | Buy |
| 3 | Vida Glow Natural Marine Collagen (Original) | Skin | $70.00 | 30 sachets | 1 sachet: marine collagen 3,000mg | $2.33 | Vida Glow |
| 4 | Eternal Elixir Magnesium L-Threonate 2000mg | Sleep | $59.99 | 90 capsules | 3 capsules: magnesium L-threonate 2,000mg (about 144mg magnesium) | $2.00 | Buy |
| 5 | Swisse Women’s Multivitamin | Everyday nutrient base | $44.99 | 60 tablets | 1 tablet: vitamin D3 25μg, B12 50μg, folic acid 500μg and more | $0.75 | Swisse |
| 6 | Eternal Elixir Trans-Resveratrol 1200mg | Bone and circulation after menopause | $59.99 | 90 capsules | 2 capsules: trans-resveratrol 1,200mg | $1.33 | Buy |
| 7 | Eternal Elixir Reduced L-Glutathione 2000mg | Skin tone | $39.99 | 90 capsules | 2 capsules: reduced glutathione 2,000mg | $0.89 | Buy |
| 8 | Nature’s Way Collagen + Hyaluronic Acid | Skin (budget) | $19.99 | 60 tablets | 3 tablets: hydrolysed collagen 2,500mg + sodium hyaluronate 150mg | $1.00 | Chemist Warehouse |
How We Compared These Supplements
Eternal Elixir makes Saffron Extract 30mg, NMN 500mg, Magnesium L-Threonate 2000mg, Trans-Resveratrol 1200mg and Reduced L-Glutathione 2000mg. Saffron is our pick, and every figure for the other three products comes from their own listings. For each product we looked at whether the ingredient has been tested in people, and ideally in women over 40; how the label dose compares with the dose in those trials; the cost per day in AUD; and how easy it is to buy in Australia.
We ranked our saffron first because it is the closest match in our range between a product and a trial in women this age: same extract, nearly the same dose. The trade-offs for every product, ours included, are in the sections below.
#1. Eternal Elixir Saffron Extract 30mg: Our Pick
Each capsule holds 30mg of saffron extract standardised to 3.5% Lepticrosalides, sold as affron. One capsule a day with a meal, 90 capsules for $49.99, is $0.56 a day.
What the trial found. In a 12-week randomised, double-blind trial, 86 women in perimenopause took 14mg of affron twice a day or a placebo (Lopresti and Smith, Journal of Menopausal Medicine, 2021). Compared with placebo, the saffron group had a bigger fall in the psychological symptom score of a standard menopause questionnaire, including a 33% drop in anxiety scores and a 32% drop in low-mood scores from the start of the trial, and a bigger fall in negative mood. Saffron did not do better than placebo for hot flushes, physical symptoms or other quality-of-life measures, and it was well tolerated.
How our dose compares. The trial used 28mg a day, split into two doses. Our capsule is 30mg once a day: slightly more, in one dose. It is the same extract.
- Suits you if: your main concerns through your 40s are mood, stress and feeling like yourself, and you want the product that matches a trial in women your age.
- Not for you if: hot flushes are the main problem (the trial found no benefit there), or you take prescription medicines for mood without your doctor’s agreement.
#2. Eternal Elixir NMN 500mg
NMN (nicotinamide mononucleotide) is a building block for NAD+, a molecule cells use to make energy. Each capsule gives 500mg, one a day, 90 capsules for $59.99, so $0.67 a day.
What the trials found. In a 60-day trial of 80 healthy middle-aged adults, men and women, 300mg, 600mg or 900mg of NMN a day raised blood NAD+ compared with placebo, with the highest levels at 600mg and 900mg. Walking distance in a six-minute test also rose more than with placebo in all three NMN groups, and no safety problems were found (Yi et al., GeroScience, 2023). A separate 10-week trial in 25 postmenopausal women who were overweight and had higher-than-normal blood sugar found that 250mg a day improved how well their muscle responded to insulin (Yoshino et al., Science, 2021). Both trials are small.
How our dose compares. 500mg a day sits between the 300mg and 600mg arms of the larger trial. Our full comparison of the best NMN supplements in Australia covers the wider evidence.
- Suits you if: you’re interested in cellular energy and want a dose in the range trials have used.
- Not for you if: you want an effect you can feel: most NMN outcomes are blood markers. Not for use in pregnancy or breastfeeding.
#3. Vida Glow Natural Marine Collagen (Original)
Each sachet holds 3,000mg of hydrolysed marine collagen from fish farmed in Europe, 30 sachets for $70.00, and the label suggests one to three a day. At one a day that is $2.33 a day. The listing showed 4.77 from 676 reviews when we checked.
What the research found. Collagen has more skin research than any other ingredient in this guide. A 2021 meta-analysis pooled 19 randomised trials with 1,125 participants aged 20 to 70, 95% of them women, and found better skin hydration, elasticity and wrinkle scores with hydrolysed collagen than with placebo (de Miranda et al., International Journal of Dermatology, 2021).
- Suits you if: skin is your main goal and you’re happy with a daily sachet stirred into a drink.
- Not for you if: you avoid fish, or want a cheaper option (Nature’s Way, #8, costs less per day).
We don’t sell collagen. For more on skin, see our guide to the best skin supplements in Australia.
#4. Eternal Elixir Magnesium L-Threonate 2000mg
Magnesium L-threonate is a form of magnesium developed, on the basis of animal research, to raise magnesium levels in the brain. Three capsules give 2,000mg of magnesium L-threonate, about 144mg of magnesium, and a 90-capsule bottle is 30 serves at $59.99, or $2.00 a day.
What the trials found. In a 21-day trial, 80 adults aged 35 to 55 with self-reported poor sleep took 1g a day of magnesium L-threonate or a placebo. Sleep quality held steady on magnesium while it declined on placebo, and ring-tracker deep and REM sleep scores were better with magnesium (Hausenblas et al., Sleep Medicine: X, 2024). A six-week trial in 100 adults aged 18 to 45 with poor sleep found 2g a day improved an overall cognition score compared with placebo (Lopresti and Smith, Frontiers in Nutrition, 2025).
How our dose compares. Our 2,000mg serve matches the 2g trial and is double the 1g sleep trial. If you’re choosing between magnesium forms, our guide to the best magnesium supplements in Australia compares them.
- Suits you if: sleep has slipped in your 40s and you want a magnesium form with sleep trials behind it.
- Not for you if: you want the cheapest way to get magnesium; other forms cost less per milligram of magnesium.
#5. Swisse Women’s Multivitamin
One tablet a day with a meal gives vitamin D3 25μg, vitamin B12 50μg, folic acid 500μg, vitamin C 165mg and a spread of other vitamins and minerals. Swisse’s own store lists 60 tablets at $44.99, or $0.75 a day, and a 120-tablet bottle at $83.99.
- Suits you if: you want one tablet as a safety net for vitamin D and B vitamins.
- Not for you if: you need real amounts of calcium (it has 42mg) or you are pregnant or planning to be, which its label warns against.
#6. Eternal Elixir Trans-Resveratrol 1200mg
Each capsule gives 600mg of trans-resveratrol, and the label serve is two capsules (1,200mg), so a 90-capsule bottle is 45 serves at $59.99, or $1.33 a day, taken with or without food.
What the trial found. The best trial here is Australian. In the RESHAW trial at the University of Newcastle, postmenopausal women aged 45 to 85 took 75mg of resveratrol twice a day or a placebo in a two-year crossover design, and 125 women completed it. After 12 months, bone density at the lower spine and hip was higher with resveratrol than placebo, and a marker of bone breakdown was 7.24% lower (Wong et al., Journal of Bone and Mineral Research, 2020).
How our dose compares, plainly. The trial used 150mg a day. Our serve is 1,200mg, eight times higher, and no trial has tested whether that amount does more for bone. Women taking warfarin were excluded from RESHAW, so talk to your doctor first if you take a blood thinner. See the best anti-ageing supplements in Australia for how resveratrol compares with other options.
- Suits you if: you’re past menopause and interested in bone and circulation.
- Not for you if: you want the trial dose exactly; ours is far above it.
#7. Eternal Elixir Reduced L-Glutathione 2000mg
Glutathione is an antioxidant your cells make. The label serve is two capsules with 2,000mg of reduced glutathione, taken on an empty stomach, so a 90-capsule bottle is 45 serves at $39.99, or $0.89 a day.
What the trial found. In a 12-week trial in Bangkok, 60 healthy women aged 20 to 50 took 250mg a day of reduced glutathione, an oxidised form, or a placebo. Melanin and wrinkle measures were lower than placebo at some skin sites, and the effect on melanin was clearer in the women over 40 (Weschawalit et al., Clinical, Cosmetic and Investigational Dermatology, 2017). The glutathione maker funded the study.
How our dose compares, plainly. Our serve is eight times the 250mg trial dose, and there is no trial showing a larger amount works better for skin. Our guide to glutathione vs vitamin C for skin goes further.
- Suits you if: an even skin tone is your goal and you like a low daily cost.
- Not for you if: you want the lowest effective amount; the trial dose was a fraction of ours.
#8. Nature’s Way Collagen + Hyaluronic Acid
Three tablets give 2,500mg of hydrolysed collagen and 150mg of sodium hyaluronate, so a 60-tablet pack lasts 20 days. It was $19.99 at Chemist Warehouse (RRP $39.99) when we checked, or $1.00 a day. The label limits use to three months.
- Suits you if: you want to try collagen cheaply from a pharmacy.
- Not for you if: you’d rather not take three tablets a day, or want to use it beyond three months.
Building a Women’s Over-40 Routine: Where to Start
Start with the basics: food, protein, resistance training, and a blood test for vitamin D, iron and B12 if you haven’t had one. Then pick one supplement for the thing that matters most to you, and give it the length of time the trials ran before you judge it.
- Mood and stress through perimenopause: saffron (affron), 12 weeks in the trial.
- Sleep: magnesium L-threonate, 3 to 6 weeks in the trials.
- Skin: collagen, with the most trials, or glutathione.
- Cellular energy: NMN, 60 days in the dose trial.
- Bone after menopause: alongside calcium and vitamin D, resveratrol had a 12-month trial, at a much lower dose than ours.
If mood and sleep are both on your list, saffron and magnesium L-threonate are a common pairing, and neither is part of one of our stacks, so you won’t double up.
Also in our range, and covered elsewhere on the blog: Spermidine 10mg, which has been studied mainly for cellular recycling, and our Grass-Fed Tallow Balm, a moisturiser for dry skin. For a fuller plan, see our longevity supplement stack guide, and for the men’s version of this list, our best supplements for men over 40.
You may also see tongkat ali marketed to women over 40. Its research is mostly in men, and only a couple of small trials have included women; our guide to tongkat ali for women covers it, and our tongkat ali Australia guide covers the ingredient in full.
Talk to your GP before starting any supplement if you take prescription medicines, including hormone therapy, or if you are pregnant or breastfeeding.
Frequently Asked Questions
What supplements should women take in their 40s?
Start with the nutrients most often advised for women 40+: vitamin D (ideally after a blood test), calcium and protein mainly from food, omega-3, fibre, and creatine if you do resistance training. Beyond those, choose by goal. Saffron (affron) has a trial in women in perimenopause for mood, magnesium L-threonate has sleep trials, and collagen has the most skin trials.
Add Saffron Extract 30mg to cart · $49.99
What does every 40-year-old woman need?
Enough protein, calcium, vitamin D and fibre, regular resistance training and sleep, and a check-up that includes blood tests your GP thinks are worth doing, such as vitamin D, iron and B12. No single supplement covers all of that.
What is the best vitamin for women over 40?
Vitamin D is the one most often recommended, because it supports bone and muscle and many people run low. Stanford Lifestyle Medicine suggests 800 to 4,000 IU a day, with a blood test to find your level. Eternal Elixir doesn’t sell vitamin D.
What is the best multivitamin for women over 40 in Australia?
Look for one tablet a day with vitamin D and B12 at useful amounts. Swisse’s Women’s Multivitamin, for example, gives 25μg of vitamin D3 and 50μg of B12 per tablet, and Swisse sells 50+ and 65+ versions for women over 60 and over 70. A multivitamin fills gaps; it won’t supply enough calcium on its own.
What is the best supplement for women over 40 in Australia?
Our pick is Eternal Elixir Saffron Extract 30mg: the affron extract used in a 12-week trial in women in perimenopause, 90 capsules for $49.99, which is $0.56 a day. Eternal Elixir makes it. If skin is your main goal, collagen has more trials, and Vida Glow and Nature’s Way are the options compared here.
Is saffron safe to take every day?
In the perimenopause trial, 28mg a day for 12 weeks was well tolerated, with no major adverse events reported. Talk to your doctor before taking it if you use prescription medicines, especially for mood, or if you are pregnant or breastfeeding.
Can I take these supplements with hormone therapy?
The trials in this guide didn’t test them alongside hormone therapy, and RESHAW excluded women using it. Ask your GP or pharmacist before combining any supplement with hormone therapy or other prescription medicines.
The Verdict
The best supplements for women over 40 start with the basics: vitamin D, calcium, protein, omega-3, fibre and, for many, creatine. For anti-ageing support on top of those, our pick is Eternal Elixir Saffron Extract 30mg, because it is the same extract that improved mood and psychological symptoms in women in perimenopause, at almost the same dose, for $0.56 a day. NMN and magnesium L-threonate come next in our range for cellular energy and sleep, and collagen is the ingredient with the most skin research.
Sources
- Stanford Lifestyle Medicine. Top 6 supplements for women 40+. lifestylemedicine.stanford.edu
- Lopresti AL, Smith SJ. The effects of a saffron extract (affron) on menopausal symptoms in women during perimenopause: a randomised, double-blind, placebo-controlled study. Journal of Menopausal Medicine. 2021;27:66-78. PubMed 34463070
- Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45:29-43. PubMed 36482258
- Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372:1224-1229. PubMed 33888596
- de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. International Journal of Dermatology. 2021;60:1449-1461. PubMed 33742704
- Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Medicine: X. 2024;8:100121. PubMed 39252819
- Lopresti AL, Smith SJ. The effects of magnesium L-threonate (Magtein) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Frontiers in Nutrition. 2025;12:1729164. PubMed 41601871
- Wong RHX, Thaung Zaw JJ, Xian CJ, Howe PRC. Regular supplementation with resveratrol improves bone mineral density in postmenopausal women: a randomized, placebo-controlled trial. Journal of Bone and Mineral Research. 2020;35:2121-2131. PubMed 32564438
- Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology. 2017;10:147-153. PubMed 28490897
- Eternal Elixir product pages (label facts, directions): Saffron Extract 30mg, NMN 500mg, Magnesium L-Threonate 2000mg, Trans-Resveratrol 1200mg, Reduced L-Glutathione 2000mg.
- Competitor listings, read on 26 September 2026: Vida Glow Natural Marine Collagen, Swisse Women’s Multivitamin, Nature’s Way Collagen + Hyaluronic Acid (Chemist Warehouse).
