AgeMate Side Effects: What Australians Should Know 2026

Last updated: September 26, 2026 · Originally published: August 7, 2026 · By Eternal Elixir Editorial

AgeMate side effects, as AgeMate itself describes them, are uncommon and mild: headaches, dizziness and an upset stomach, which its FAQ says happen “in some very rare cases”. The label sets firmer limits. The powder is for adults only, not recommended in pregnancy or breastfeeding, contains phenylalanine and sulfites, and is meant for daily use for up to 12 weeks unless a health professional advises otherwise. The check most people miss is vitamin K2: each scoop has 180 mcg, which matters if you take a warfarin-type blood thinner. If you want the NMN without 14 other actives, our pick is Eternal Elixir NMN 500mg.

This guide covers the side effects AgeMate and the research describe, who should not take AgeMate, why a 15-active blend makes a reaction hard to trace, what the human NMN trials found, and what to do if the scoop disagrees with you.

Key numbers:

• 15 actives in one 3.325 g AgeMate scoop, including 500 mg of NMN.
• 180 mcg of vitamin K2 per scoop, four times the highest dose that shifted clotting tests in a trial of people on an anticoagulant.
• 12 weeks: the daily-use period in AgeMate’s directions.
• 1,250 mg of NMN a day for 4 weeks produced no severe adverse events in a trial of 31 healthy adults, 2.5 times the dose in a scoop.

What AgeMate side effects are actually reported

Three sources describe what people notice, and they point the same way.

• AgeMate’s FAQ says NMN is considered safe for most people, but that “in some very rare cases NMN can cause headaches, dizziness, and an upset stomach”. It adds that NMN may interact with medications the company is not aware of, and asks anyone on prescription drugs to speak to their doctor first.
• AgeMate’s article on NMN side effects lists mild digestive discomfort such as nausea or stomach upset, headaches, and temporary changes in how the body feels, and describes them as mild and transient.
• Human trials of NMN on its own have not found more adverse events than placebo. A 2026 meta-analysis of 15 randomised trials, covering 250 mg to 2,000 mg a day for 14 days to 24 weeks, found no increase in overall, serious or withdrawal-related adverse events.

None of these sources tested the AgeMate blend itself. The trials gave NMN alone, and the company’s statements are about NMN. We found no published trial of the Daily Longevity Blend. So a reaction to AgeMate could come from any of its 15 actives, which is the problem the rest of this guide deals with. Our comparison of AgeMate alternatives in Australia sets the blend against single-ingredient options, and our breakdown of every AgeMate ingredient covers what each active is there for.

Who should not take AgeMate

AgeMate’s own label and FAQ rule out some people outright, and a close read of the panel adds more.

• Children and teenagers. The label says adults only.
• Pregnant or breastfeeding women. The label says not recommended, and the FAQ advises against NMN while pregnant or breastfeeding. NMN trials exclude these groups, so there is no human safety data to go on.
• People who must limit phenylalanine, or who react to sulfites. The label says the powder contains both.
• Anyone on a warfarin-type blood thinner. Each scoop has 180 mcg of vitamin K2 as menaquinone-7 (MK-7), and vitamin K works against these medicines. In a trial of 18 healthy volunteers kept on the anticoagulant acenocoumarol, MK-7 at 45 mcg a day lowered the average INR, a clotting test, by about 40%. Even 10 mcg a day produced a clinically relevant INR drop in at least 40% of participants, and the authors concluded that people on these medicines should avoid MK-7 supplements. An AgeMate scoop has four times the highest dose tested. Talk to your doctor before starting.
• Anyone on other prescription medicines. AgeMate asks you to speak to your doctor first, and its own article says NMN’s interactions with medicines have not been fully characterised in humans.
• People already taking a multivitamin. The scoop adds zinc, folate, vitamin B12, biotin, vitamin B1, vitamin C and vitamin D3, so stacking it on another multi doubles up on several of them.

AgeMate’s directions also set a time frame: daily for up to 12 weeks, or as advised by your healthcare professional. If you plan to take it all year, raise that with your doctor rather than skipping past it. Our roundup of AgeMate reviews in Australia covers how buyers use it in practice.

Why a 15-active blend makes a reaction hard to trace

With a single-ingredient capsule, a reaction has one suspect. With an all-in-one scoop, it has 15. The current label lists, per 3.325 g scoop:

• Glycine 1.1 g and CellVive NMN 500 mg
• Magnesium citrate 300 mg, which supplies about 46 mg of elemental magnesium according to the label’s equivalence note
• MSM 300 mg, vitamin C 250 mg and L-theanine 200 mg
• Choline bitartrate 55 mg, dimethylglycine 50 mg and vitamin B1 25 mg
• Zinc 4 mg (from 12 mg of zinc citrate), folate 300 mcg, vitamin K2 180 mcg, biotin 100 mcg, vitamin B12 50 mcg and vitamin D3 1,000 IU

Natural flavours, beetroot and blue spirulina for colour, thaumatin as a sweetener, citric acid and silicon dioxide make up the rest.

Some of these actives have known effects of their own at high intakes. Large amounts of vitamin C can cause diarrhoea, nausea and cramps when the unabsorbed vitamin draws water into the gut, and supplemental magnesium can loosen stools. The usual adult upper levels are 2,000 mg a day for vitamin C and 350 mg a day for magnesium from supplements. A scoop gives 250 mg of vitamin C and about 46 mg of magnesium, well under both. The complaints AgeMate lists are the ones it puts down to NMN, but the label cannot tell you which active caused yours.

Symptom-first map

Use the table as a starting point for a conversation with your pharmacist, not as a diagnosis.

What the human research says about NMN tolerability

NMN is the headline ingredient, so it collects most of the suspicion. These are the trials that measured safety directly:

• 31 healthy adults aged 20 to 65 took 1,250 mg of NMN or a placebo once a day for 4 weeks (Fukamizu and colleagues, Scientific Reports, 2022). Blood, urine and body-composition measures stayed within normal variation, and there were no severe adverse events. That dose is 2.5 times the 500 mg in a scoop. Five of the six authors worked for Mitsubishi Corporation Life Sciences, which supplied the NMN.
• 80 healthy middle-aged adults took a placebo or 300 mg, 600 mg or 900 mg of NMN daily for 60 days (Yi and colleagues, GeroScience, 2023). All 80 completed the trial, and adverse-event monitoring and laboratory tests raised no safety issues up to 900 mg.
• 60 older adults took 250 mg of NMN or a placebo daily for 12 weeks (Morifuji and colleagues, GeroScience, 2024), with no adverse effects linked to NMN.
• The 2026 meta-analysis of 15 trials (Yang and colleagues, Nutrients) found that NMN did not raise adverse events or the liver enzymes ALT and AST compared with control groups.

These are short studies in healthy adults, several funded or run by NMN makers, and none lasted longer than 24 weeks. They tested NMN alone, not a 15-active blend. What they show is that 500 mg of NMN sits well inside the range healthy adults have tolerated in trials. If something in the scoop disagrees with you, NMN is one candidate among several. Our NMN dosage guide for Australia maps the trial doses onto what is sold here, and our look at AgeMate’s 500 mg NMN dose compares the scoop with trial amounts.

Morning or afternoon: timing is one thing you can test

AgeMate directs you to take the scoop in the morning. One randomised trial has compared NMN timing head to head. In it, 108 older Japanese adults took 250 mg of NMN or a placebo once a day for 12 weeks, either in the morning or in the afternoon (Kim and colleagues, Nutrients, 2022). Sit-to-stand times improved in every group, placebo included, and the afternoon NMN group showed the largest effect on that test and on drowsiness.

That was an older group on half AgeMate’s NMN dose, so treat it as a signal, not a rule. If your complaint is feeling sleepy or flat at the wrong time of day rather than a stomach issue, changing when you take the scoop is a cheaper test than stopping. The catch with a blend is that moving the scoop moves the glycine and theanine too. Our guide to how long NMN takes to work covers what to expect week by week from NMN on its own.

If you react: how to work out what it was

1. Stop and note how quickly it clears. AgeMate’s article describes NMN side effects as mild and transient. If a symptom is severe, or you notice itching, a rash or other signs of sensitivity, stop and get medical advice.
2. If it cleared, decide whether to try again. AgeMate’s directions allow the scoop with or without food, so taking it with breakfast is a reasonable second attempt. Keep everything else the same so the test tells you something.
3. If it comes back, the blend may not suit you. The only way to find the active responsible is to take ingredients one at a time. Starting with NMN alone tells you whether the headline ingredient is the problem.

Talk to your doctor or pharmacist at any step if you take prescription medicines or have a health condition.

A single-ingredient NMN capsule instead

This is where our NMN 500mg fits. Its ingredient list is NMN 500 mg per capsule, rice flour and a cellulose capsule. There is no vitamin K2, flavour, colour or sweetener in it, so if you feel something, you know it came from the NMN. One capsule gives the same 500 mg of NMN as an AgeMate scoop.

Eternal Elixir makes NMN 500mg, and it is our pick for anyone who wants NMN they can trace, at about a quarter of AgeMate’s subscribed price per serve. The trade-off is real: an NMN capsule replaces none of AgeMate’s glycine, theanine or vitamins, so if you take AgeMate for those, a capsule is not a like-for-like swap.

Orders ship from Sydney within 24 hours, with a 30-day money-back guarantee, Afterpay, and free shipping over $100. If NMN itself turns out not to suit you, our Pure NR 500mg is the other main NAD+ precursor. In a 2026 trial of 65 healthy adults, 1,000 mg a day of NR and 1,000 mg a day of NMN raised blood NAD+ by a similar amount over 14 days. If you later want to add resveratrol, add it on its own once NMN has settled, so you keep to one change at a time. Our Trans-Resveratrol 1200mg gives 1,200 mg per two-capsule serve.

Add NMN 500mg to cart · $59.99

For the wider picture, our Simply Nootropics vs AgeMate comparison and Tmrw vs AgeMate comparison cover the other NMN options, our AgeMate price breakdown covers every plan, and our guide to the best NMN supplements in Australia compares the field on dose and cost.

AgeMate side effects: frequently asked questions

Does AgeMate cause diarrhoea or an upset stomach?

AgeMate lists an upset stomach among the rare effects of NMN, and its article mentions nausea. On the label, vitamin C and magnesium citrate can also upset the gut at high intakes, though a scoop gives far less than the usual upper levels (250 mg of vitamin C and about 46 mg of magnesium). Taking the scoop with food, which the directions allow, is a reasonable first step. If it persists, stop and talk to your doctor or pharmacist.

How long do AgeMate side effects last?

AgeMate describes NMN side effects as mild and transient. No published data tracks how long they last on the blend itself. If a symptom is severe, or does not settle once you stop, talk to your doctor rather than pushing through.

Is NMN toxic to the liver?

Short-term human data says no. The 2026 meta-analysis of 15 randomised trials found NMN did not raise the liver enzymes ALT and AST compared with control groups, at 250 mg to 2,000 mg a day for 14 days to 24 weeks. The 1,250 mg safety trial also found blood biochemistry within normal variation over 4 weeks. There is no human data beyond about six months, so anyone with a liver condition should ask their doctor first.

What are the risks of taking NMN?

In trials of healthy adults, NMN at 250 mg to 2,000 mg a day for up to 24 weeks has not caused more adverse events than placebo. The open questions are the unknowns: no long-term human data, no data in pregnancy or breastfeeding, and interactions with medicines not fully characterised. A blend like AgeMate adds the considerations of its other actives, such as vitamin K2 for anyone on a blood thinner.

Does AgeMate actually work?

It depends what you want it to do. Its 500 mg of NMN sits inside the range that raised blood NAD+ in trials, which used 250 mg to 900 mg a day. We found no published trial of the AgeMate blend itself, so there is no direct evidence for the formula as sold, and no human trial has shown that NMN extends lifespan. Our AgeMate reviews breakdown covers what buyers report.

Can you take AgeMate at night?

AgeMate’s directions say morning. The one randomised timing trial found afternoon NMN gave the largest effect on sit-to-stand times and drowsiness in older adults taking 250 mg a day. Moving the scoop later also moves its glycine and theanine, so if you try it, change only the timing and watch how you sleep.

What can I take instead of AgeMate?

If you want the NMN, our pick is Eternal Elixir NMN 500mg: the same 500 mg per serve in one capsule, with no other actives, at $0.67 a day. It makes any reaction traceable and lets you adjust the dose on its own. Our guide to AgeMate alternatives compares eight NMN options, and our note on where AgeMate is sold in Australia covers buying it locally.

Add NMN 500mg to cart · $59.99

The bottom line

AgeMate’s reported side effects are mild and uncommon, but the label rules out children, pregnancy and breastfeeding, and anyone avoiding phenylalanine or sulfites, and its 180 mcg of vitamin K2 makes it a doctor conversation for anyone on a blood thinner. Because the scoop holds 15 actives, a reaction is hard to trace. If NMN is what you are after, one Eternal Elixir NMN 500mg capsule gives the same 500 mg with nothing else to rule out, for $0.67 a day. You can also browse the full Eternal Elixir range.

Sources

• AgeMate Daily Longevity Blend product page, label and directions, checked 26 September 2026. agemate.com
• AgeMate FAQs, checked 26 September 2026. agemate.com/pages/faqs
• AgeMate, “NMN: Side Effects and Safety Considerations”, checked 26 September 2026. agemate.com
• Theuwissen E, Teunissen KJ, Spronk HM, et al. Effect of low-dose supplements of menaquinone-7 (vitamin K2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. Journal of Thrombosis and Haemostasis. 2013;11(6):1085-92. PubMed 23530987
• Fukamizu Y, Uchida Y, Shigekawa A, et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Scientific Reports. 2022;12(1):14442. PubMed 36002548
• Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43. PubMed 36482258
• Morifuji M, Higashi S, Ebihara S, Nagata M. Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. GeroScience. 2024;46(5):4671-4688. PubMed 38789831
• Kim M, Seol J, Sato T, et al. Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: a randomized, double-blind placebo-controlled study. Nutrients. 2022;14(4):755. PubMed 35215405
• Yang W, Huang J, Tang Z, et al. Safety and metabolism-related outcomes of oral nicotinamide mononucleotide supplementation in adults: a systematic review and meta-analysis. Nutrients. 2026;18(14):2251. PubMed 42514320
• Christen S, Redeuil K, Goulet L, et al. The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans. Nature Metabolism. 2026;8(1):62-73. PubMed 41540253
• Vitamin C and magnesium fact sheets for health professionals (upper levels and gastrointestinal effects). Vitamin C, Magnesium