Best Mitochondrial Support Supplements in Australia 2026: 8 Cellular Energy Products Compared

Last updated: September 26, 2026 · Originally published: May 12, 2026 · By Eternal Elixir Editorial

Mitochondria are the parts of your cells that turn food and oxygen into ATP, the energy every cell runs on. Mitochondrial support supplements work on different steps of that process. Some supply NAD+ precursors (NMN, NR), some carry electrons along the energy chain (CoQ10, methylene blue), one is a Krebs cycle metabolite (Ca-AKG), and one is sold as a signal for making new mitochondria (PQQ). This guide compares eight mitochondrial health supplements sold in Australia on AUD price, dose per serve, cost per day and what the human trials measured, including where the trials found nothing.

Best Mitochondrial Supplements in Australia: Comparison Table

Prices as of Sep 2026, read from each listing on 26 September 2026. Cost per day uses each label’s own daily serve. Eternal Elixir prices are for one bottle. Two bottles save 10%, three save 15% and five save 20%.

Healthy Care CoQ10 costs the least per day. Eternal Elixir’s NMN, NR, Ca-AKG and pterostilbene are one capsule a day from a 90-capsule bottle, so one bottle lasts three months. The Life Extension formula lasts 30 days at four capsules a day.

How Mitochondrial Support Supplements Work, and What Hasn’t Been Shown

Inside each mitochondrion, the Krebs cycle pulls electrons from the food you eat and loads them onto NAD+. The electrons then pass along a chain of proteins called the electron transport chain, with coenzyme Q10 carrying them part of the way, and that flow drives ATP production. Your body makes its own CoQ10, and it is an essential part of that chain (Hernández-Camacho et al., 2018). Each supplement below targets one part of the system:

• NAD+ precursors (NMN and NR). Both raised NAD+ in blood in human trials. Whether that improves how mitochondria work in muscle is less clear. One NR trial that measured it directly found no change.
• Electron carriers (CoQ10 and methylene blue). CoQ10 is part of the chain your body already runs. Methylene blue can pick up and pass on electrons in cell studies.
• A Krebs cycle metabolite (Ca-AKG). Alpha-ketoglutarate is one of the cycle’s own intermediates. Most of its evidence comes from mice.
• A biogenesis signal (PQQ). In one small human trial, PQQ raised a protein linked with making new mitochondria.

Here is what hasn’t been shown. None of these supplements has been shown to increase mitochondrial capacity in healthy people the way exercise does. In a Mayo Clinic trial, 12 weeks of high-intensity interval cycling three days a week raised muscle mitochondrial respiration by 49% in adults aged 18 to 30 and by 69% in adults aged 65 to 80 (Robinson et al., 2017). Treat supplements as an add-on to training, sleep and diet, not a substitute.

#1. Eternal Elixir NMN 500mg: Our Pick for Most People

Key specs: 500mg NMN per capsule · 90 capsules · one capsule a day · $59.99 (usually $64.99) · about $0.67 a day · ships from Sydney

NMN is one step away from NAD+ in the body’s own recycling pathway, which is why it is the first thing we suggest for mitochondrial support. It also has the clearest human dose data of anything in our range. In a randomised, double-blind trial, 80 healthy middle-aged adults took a placebo or 300mg, 600mg or 900mg of NMN once a day for 60 days. Blood NAD+ rose in every NMN group by day 30 and was still higher at day 60, with the highest levels at 600mg and 900mg. Six-minute walking distance improved more than placebo in all three NMN groups, and the researchers found no safety problems (Yi et al., GeroScience, 2023). Two limits matter. NMN manufacturers funded the trial, and it measured NAD+ in blood, not mitochondrial function in muscle.

Our dose against the trial: our serve is one 500mg capsule, between the 300mg and 600mg groups. That is below the 600mg dose that gave the best NAD+ and walking results in that trial.

How it compares on price: Bulk Nutrients sells NMN capsules at A$79 for 120 capsules of 500mg, about A$0.66 a capsule, which is a cent less per capsule than ours. Bulk charges a flat $9 for shipping. We ship free on orders over $100, so the difference evens out if you are buying more than one product.

• Who it suits: adults who want a daily NAD+ precursor with a human dose-ranging trial behind it, and anyone starting a longevity stack.
• Who it doesn’t suit: anyone expecting a quick energy lift, because the trial measured changes over weeks. If you are pregnant, breastfeeding or take prescription medicines, talk to your doctor first.

For brand-by-brand NMN comparisons, see our NMN buying guide and the wider NAD+ supplements comparison.

#2. Eternal Elixir Pure NR 500mg: The Alternative NAD+ Precursor

Key specs: 500mg nicotinamide riboside per capsule · 90 capsules · one capsule a day · $59.99 · about $0.67 a day

NR is the other main NAD+ precursor. It has two useful human trials, and one of them is a clear negative for mitochondrial function:

• NAD+ rose. In a randomised, double-blind crossover trial, 30 healthy middle-aged and older adults were randomised and 24 completed six weeks each of NR (500mg twice a day, so 1,000mg a day) and placebo. NAD+ in blood immune cells was about 60% higher on NR than on placebo. Exercise capacity (VO2max) did not change (Martens et al., Nature Communications, 2018).
• Mitochondrial function didn’t. In 13 healthy adults with overweight, 1,000mg of NR a day for six weeks raised NAD+ markers in muscle, but had no effect on mitochondrial function, insulin sensitivity or energy metabolism (Remie et al., American Journal of Clinical Nutrition, 2020).

Our dose against the trials: our label serve is one 500mg capsule, which is half the 1,000mg a day used in both trials.

How it compares: the NR product at Chemist Warehouse, Hydra Longevity Cellular Energy, has 300mg of NR per capsule with 150mg of resveratrol, 6mcg of vitamin B12 and 210mg of magnesium glycinate, at A$65 for 30 capsules. That is about $2.17 a day. Ours has more NR per capsule (500mg) at under a third of the daily cost.

• Who it suits: people who prefer NR to NMN, or who want the precursor with the longer trial record.
• Who it doesn’t suit: anyone already taking NMN. They feed the same pathway, so pick one.

Not sure which precursor to choose? Our NMN vs NR comparison goes through both in detail. See Pure NR 500mg.

#3. Healthy Care CoEnzyme Q10 150mg: Lowest Cost per Day (Chemist Warehouse)

Key specs: 150mg CoQ10 (listed as ubidecarenone, the ubiquinone form) per capsule · 100 capsules · one capsule a day with food · A$20.99 at Chemist Warehouse (RRP A$34.99) · about A$0.21 a day

CoQ10 is the supplement most people mean when they ask about mitochondria. It carries electrons inside the energy chain and also works as an antioxidant in cell membranes. The human performance data are small. In a double-blind crossover trial, 17 healthy volunteers took 100mg or 300mg of CoQ10 a day, or a placebo, for eight days, then did a long, tiring cycling test. At 300mg, they held their sprint speed better and felt less fatigue than on placebo (Mizuno et al., Nutrition, 2008).

Dose against the trial: 150mg is half the 300mg dose that made a difference in that trial.

The label says it contains soya oil and not to take it while on warfarin without medical advice. If you need a soy-free option, Herbs of Gold CoQ10 150mg uses a rice bran oil base and costs A$69.95 for 60 capsules on the Herbs of Gold site (A$55.96 in a sale when we checked). That is about A$1.17 a day at the full price.

• Who it suits: anyone on a budget, and people who want to pick up a mitochondrial supplement in a pharmacy today.
• Who it doesn’t suit: people who avoid soy, and anyone on warfarin who hasn’t spoken to their doctor. We don’t sell CoQ10.

#4. Eternal Elixir Methylene Blue 10mg Capsules: Best Low-Dose Methylene Blue

Key specs: 10mg methylene blue USP per capsule · 60 capsules · one capsule a day · $59.99 (usually $69.99) · $1.00 a day

Methylene blue can accept electrons and pass them to cytochrome c, a step in the energy chain. In human skin cells grown in the lab, very low concentrations raised complex IV activity by 30% and oxygen use by 37% to 70% (Atamna et al., FASEB Journal, 2008). That is a cell study, so it tells you how the molecule behaves, not what a capsule does in your body.

The main human trial gave 26 healthy adults aged 22 to 62 a single 280mg dose (about 4mg per kg) or a placebo, 13 people in each group. One hour later, brain scans showed more activity during attention and short-term memory tasks, and correct answers in memory retrieval rose 7% (Rodriguez et al., Radiology, 2016). That trial measured brain activity after one dose, not mitochondria.

Our dose against the trial: our capsule is 10mg, one twenty-eighth of the 280mg tested. We found no trial of 10mg a day that measured mitochondrial or memory outcomes.

Safety first: methylene blue must not be combined with SSRIs, SNRIs, MAOIs or other serotonergic medicines, because of the risk of serotonin toxicity. A fatal case after methylene blue in a person taking venlafaxine has been reported (Top et al., 2014). Don’t take it if you have G6PD deficiency, are pregnant or breastfeeding, or are under 18. It can turn urine blue or green. Talk to your doctor if you take any prescription medicine, and read our methylene blue safety guide before starting.

• Who it suits: adults on no serotonergic medicines who want to try methylene blue at a low daily dose.
• Who it doesn’t suit: anyone on antidepressants or other serotonergic medicines, and anyone who wants trial-proven results at the dose they take.

Compare brands in our best methylene blue supplements guide.

#5. Eternal Elixir Ca-AKG 500mg: A Krebs Cycle Metabolite

Key specs: 500mg calcium alpha-ketoglutarate per capsule · 90 capsules · one capsule a day · $59.99 · about $0.67 a day

Alpha-ketoglutarate (AKG) is one of the Krebs cycle’s own intermediates, and its levels in the body change with fasting, exercise and age. The calcium salt, Ca-AKG, is the form used in the research. Be clear about what that research is:

• Mice. Mice fed Ca-AKG from middle age lived longer, were less frail and had lower levels of inflammatory markers (Asadi Shahmirzadi et al., Cell Metabolism, 2020). Mouse results don’t tell us what happens in people.
• People, without a control group. A retrospective analysis of 42 people who took an AKG and vitamin formula for about seven months found a lower DNA-methylation age estimate at the end (Demidenko et al., Aging, 2021). There was no placebo group, and one author sat on the board of the company selling the formula.

We found no controlled human trial of Ca-AKG that measured mitochondrial function, so we can’t compare our 500mg serve with a proven human dose.

• Who it suits: people who want to add AKG to a stack and are comfortable with early evidence.
• Who it doesn’t suit: anyone who wants a supplement with human trial results for mitochondria.

See Ca-AKG 500mg or read how it fits in our longevity supplement stack guide.

#6. California Gold Nutrition PQQ 20mg: Lowest-Cost Single PQQ

Key specs: 20mg PQQ (disodium salt) per capsule · 60 capsules · one capsule a day with food · A$25.98 at iHerb AU · about A$0.43 a day

PQQ is sold for mitochondrial biogenesis, the process of making new mitochondria. The best human test we found is small. In a randomised trial, 23 untrained men took 20mg of PQQ a day or a placebo for six weeks while following the same supervised endurance training program. PQQ gave no extra gain in aerobic performance or body composition, but the PQQ group had a bigger rise in PGC-1α, a protein linked with making new mitochondria (Hwang et al., Journal of the American College of Nutrition, 2020).

Dose against the trial: 20mg matches the trial dose.

• Who it suits: people who train and want to try PQQ on its own at the dose used in research.
• Who it doesn’t suit: anyone hoping for better fitness results, which the trial didn’t find. We don’t sell PQQ.

#7. Eternal Elixir Trans-Pterostilbene 500mg: A Polyphenol Add-On

Key specs: 500mg trans-pterostilbene per capsule · 90 capsules · one capsule a day · $64.99 · about $0.72 a day

Pterostilbene is a close chemical relative of resveratrol. It sits in this list because people often stack it with NMN, not because of mitochondrial trial data. The main human study was a safety trial: 80 adults with an average age of 54 took up to 125mg twice a day (250mg a day) or a placebo for six to eight weeks, with no adverse effects on liver, kidney or glucose markers (Riche et al., Journal of Toxicology, 2013). We found no human trial of pterostilbene that measured mitochondrial function.

Our dose against the trial: our capsule is 500mg, double the highest daily dose in that safety trial.

If you want NMN and pterostilbene together, the Cellular Longevity Stack combines NMN, spermidine and trans-pterostilbene for $139.99, against $174.97 for the three bottles bought separately.

• Who it suits: people already taking NMN who want a polyphenol in the same routine.
• Who it doesn’t suit: anyone choosing a single mitochondrial supplement. Start with NMN or CoQ10 instead.

See Trans-Pterostilbene 500mg, or compare it with resveratrol in our resveratrol supplements guide.

#8. Life Extension Mitochondrial Energy Optimizer with PQQ: Most Actives in One Formula

Key specs: per four-capsule serve, 1,000mg carnosine, 800mg taurine, 150mg benfotiamine, 150mg R-lipoic acid, 100mg vitamin B6 and 10mg PQQ · 120 capsules (30 serves) · two capsules twice a day without food · A$81.12 at iHerb AU · about A$2.70 a day

This is the one-bottle option: six actives in a single formula, sold in Australia through iHerb. The current label lists no CoQ10. We found no trial of this formula, and its 10mg of PQQ is half the 20mg used in the PQQ trial above. The 100mg of vitamin B6 is listed at 5,882% of the reference intake, so check your total B6 from any other supplements with your pharmacist.

• Who it suits: people who want several ingredients in one product and don’t mind four capsules a day.
• Who it doesn’t suit: anyone on a budget, as it is the most expensive per day here, and anyone already taking B6 in another supplement.

Mitochondria Supplements at Chemist Warehouse vs Specialist Brands

If you want to buy in person, Chemist Warehouse stocks CoQ10, including the Healthy Care CoQ10 150mg at #3, and one NR product, Hydra Longevity Cellular Energy, which is 300mg of NR per capsule at A$65 for 30 capsules.

For PQQ supplements at Chemist Warehouse, the listing we found was Hydra Longevity Healthy Ageing, a 180g powder at A$99 for 30 serves of 6g. Its PQQ sits inside a 1,450mg blend with six other ingredients, and the listing gives no separate PQQ amount. If you want to know how much PQQ you are taking, a single-ingredient capsule such as the California Gold Nutrition PQQ 20mg at #6 is the clearer choice.

Eternal Elixir’s NMN, NR, methylene blue, Ca-AKG and pterostilbene are sold on our own site, ship from Sydney within 24 hours and come with a 30-day money-back guarantee.

Building a Mitochondrial Support Stack

Most people don’t need everything on this list. Start with one product, give it at least 30 days, and only then decide whether to add a second from a different category. A few rules keep a stack sensible:

• Pick one NAD+ precursor. NMN and NR feed the same pathway. We found no trial of the two together.
• Pair across categories, not within them. NMN with Ca-AKG covers NAD+ and a Krebs cycle metabolite. No trial has tested that pair, so treat it as a sensible combination rather than a proven one.
• Keep methylene blue for people on no serotonergic medicines. If you want to combine it with NMN, our methylene blue and NMN stacking guide covers timing and safety.

For energy more broadly, see our energy supplements comparison, and for age-specific picks, the guides for men over 40 and anti-ageing supplements.

How We Ranked These Mitochondrial Health Supplements

We looked at four things for each product:

• Human evidence. Is there a controlled human trial of the ingredient, and did it measure NAD+, mitochondrial function or something close to it? We say where a trial found nothing and where the evidence is only in cells or mice.
• Dose against the trials. Is the serve on the label above, below or equal to the dose the trials used?
• Cost per day in AUD. The listed price divided by the number of daily serves on the label.
• Buying in Australia. Whether you can buy it locally, in a pharmacy or through an Australian storefront.

Eternal Elixir makes five of the eight products, and our NMN is our pick at #1. Competitor facts come from each brand’s or retailer’s live listing on 26 September 2026, and each competitor keeps the label it earns, such as the lowest cost per day.

FAQ: Mitochondrial Supplements in Australia

What is the best mitochondrial supplement in Australia?

Our pick is Eternal Elixir NMN 500mg: 500mg per capsule, 90 capsules and about $0.67 a day, backed by a 60-day human trial in which 300mg to 900mg a day raised blood NAD+. Eternal Elixir makes it. If you would rather take CoQ10, Healthy Care CoQ10 150mg has the lowest cost per day in our comparison at $0.21.

Add NMN 500mg to cart · $59.99

Do mitochondrial supplements really work?

Some change the marker they are meant to change. NMN and NR raise NAD+ in blood in human trials, and PQQ raised a protein linked with new mitochondria in a trial of 23 men. When researchers measured mitochondrial function directly in muscle after six weeks of 1,000mg of NR a day, it didn’t change. None of them has matched the gains seen with exercise training, so expect support rather than a transformation.

What rebuilds your mitochondria?

Exercise has the strongest human evidence. In the Mayo Clinic trial, 12 weeks of high-intensity interval cycling three days a week raised muscle mitochondrial respiration by 49% in younger adults and 69% in older adults. Supplements such as NMN or PQQ may support parts of the process, but the trial evidence for building mitochondrial capacity is clearest for training.

What are the symptoms of having low mitochondria?

There is no reliable symptom checklist. Ongoing tiredness, poor exercise tolerance and brain fog have many possible causes, including sleep, low iron and medical conditions. See your GP for tests before assuming the problem is your mitochondria. Inherited mitochondrial disease is a medical diagnosis that needs specialist care, not supplements.

Can I buy mitochondrial supplements at Chemist Warehouse?

Yes, some. Chemist Warehouse sells CoQ10, including Healthy Care CoQ10 150mg at A$20.99 for 100 capsules, and Hydra Longevity Cellular Energy, which has 300mg of NR per capsule. The PQQ we found there is inside a powder blend without a separate PQQ amount. For NMN, methylene blue capsules, Ca-AKG or pterostilbene, you can order from Eternal Elixir with free shipping over $100.

NMN vs methylene blue: which is better for mitochondrial support?

They work on different steps. NMN supplies a building block for NAD+, and a human trial covered doses around ours. Methylene blue passes electrons along the energy chain in cell studies, but its human trial used a single 280mg dose, far above our 10mg capsule, and it interacts with serotonergic medicines. For most people, NMN is the simpler place to start. See our guide to taking methylene blue with NMN if you want both.

Add Methylene Blue 10mg to cart · $59.99

How much do mitochondrial supplements cost in Australia?

Across the eight products here, the cost runs from A$0.21 a day for Healthy Care CoQ10 to A$2.70 a day for Life Extension’s four-capsule formula. Eternal Elixir’s products cost $0.67 to $1.00 a day, and multi-bottle orders save 10% on two, 15% on three and 20% on five.

How long do mitochondrial supplements take to work?

Go by what the trials measured. Blood NAD+ was already higher at day 30 in the NMN trial. The NR and PQQ trials ran for six weeks. The methylene blue brain-scan result came one hour after a single 280mg dose, which is far above the amount in a 10mg capsule. Give any of these at least four to eight weeks before you judge it.

The Bottom Line

The best mitochondrial supplements work on different parts of cellular energy production, and the evidence behind them ranges from human trials to mouse studies. Our pick is Eternal Elixir NMN 500mg: 500mg a capsule, 90 capsules, about $0.67 a day, and a human trial showing higher blood NAD+ across doses on either side of ours. If you want the lowest cost, Healthy Care CoQ10 150mg from Chemist Warehouse is $0.21 a day. Whatever you choose, pair it with regular exercise, which has the strongest evidence for building mitochondrial capacity.

Sources

1. Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43. PubMed 36482258
2. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018;9:1286. PubMed 29599478
3. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. American Journal of Clinical Nutrition. 2020;112(2):413-426. PubMed 32320006
4. Hernández-Camacho JD, Bernier M, López-Lluch G, Navas P. Coenzyme Q10 supplementation in aging and disease. Frontiers in Physiology. 2018;9:44. PubMed 29459830
5. Mizuno K, Tanaka M, Nozaki S, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24(4):293-299. PubMed 18272335
6. Atamna H, Nguyen A, Schultz C, et al. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB Journal. 2008;22(3):703-712. PubMed 17928358
7. Rodriguez P, Zhou W, Barrett DW, et al. Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain. Radiology. 2016;281(2):516-526. PubMed 27351678
8. Top WM, Gillman PK, de Langen CJ, Kooy A. Fatal methylene blue associated serotonin toxicity. Netherlands Journal of Medicine. 2014;72(3):179-181. PubMed 24846936
9. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metabolism. 2020;32(3):447-456. PubMed 32877690
10. Demidenko O, Barardo D, Budovskii V, et al. Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021;13(22):24485-24499. PubMed 34847066
11. Hwang PS, Machek SB, Cardaci TD, et al. Effects of pyrroloquinoline quinone (PQQ) supplementation on aerobic exercise performance and indices of mitochondrial biogenesis in untrained men. Journal of the American College of Nutrition. 2020;39(6):547-556. PubMed 31860387
12. Riche DM, McEwen CL, Riche KD, et al. Analysis of safety from a human clinical trial with pterostilbene. Journal of Toxicology. 2013;2013:463595. PubMed 23431291
13. Robinson MM, Dasari S, Konopka AR, et al. Enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans. Cell Metabolism. 2017;25(3):581-592. PubMed 28273480
14. Eternal Elixir product pages (label facts, directions, multi-bottle pricing): NMN 500mg, Pure NR 500mg, Methylene Blue 10mg, Ca-AKG 500mg, Trans-Pterostilbene 500mg, Cellular Longevity Stack, Spermidine 10mg.
15. Competitor listings, read on 26 September 2026: Healthy Care CoEnzyme Q10 150mg (Chemist Warehouse), Herbs of Gold CoQ10 150mg, California Gold Nutrition PQQ 20mg (iHerb AU), Life Extension Mitochondrial Energy Optimizer with PQQ (iHerb AU), Hydra Longevity Cellular Energy (Chemist Warehouse), Hydra Longevity Healthy Ageing 180g (Chemist Warehouse), Bulk Nutrients NMN Capsules.