TMG 2000mg | Trimethylglycine for Methylation & Liver Support

TMG stands for trimethylglycine: the amino acid glycine carrying three methyl groups. It was first isolated from sugar beet, which is where the name betaine comes from, and it occurs naturally in beetroot, spinach, wheat bran and quinoa. The supplement form is betaine anhydrous, which is the form in each capsule.

When NAD+ is used, it releases nicotinamide, which the body clears by attaching a methyl group to it through the enzyme NNMT. Raising NAD+ with NMN or NR increases the demand on your methyl reserves. TMG replenishes those reserves and keeps homocysteine in check. Whether every NMN user strictly needs it is still debated in the research, but it is inexpensive insurance. Take it with your morning NMN.

TMG donates a methyl group directly to homocysteine through the liver enzyme BHMT, converting it back into methionine. In a six-week randomised trial of healthy adults, 1.5 g and 3 g of betaine a day lowered fasting homocysteine by 12% and 15% respectively, and blunted the homocysteine spike after a methionine-rich meal by up to 40%. Our 2,000 mg serve sits inside that range. Because it works through a different pathway from folate and B12, it complements rather than replaces them.

Three capsules a day with a meal, which gives 2,000 mg of betaine anhydrous. You can take all three at breakfast alongside NMN or NR. Splitting the serve across two meals is fine too. If you are targeting a specific homocysteine result, work with your doctor and retest after six to eight weeks.

Yes. Betaine is concentrated in the liver, where it does two jobs. It acts as an osmolyte that helps liver cells manage water balance under stress, and it supplies the methyl groups the liver needs to package and export fat. That is why it is studied for liver health and healthy fat metabolism. For extra liver support, it pairs well with our TUDCA.

No. Betaine HCl is a hydrochloride salt sold as a digestive aid to increase stomach acid, and it is not the right form for methylation. Betaine anhydrous, the pure trimethylglycine in this product, is the form used in the homocysteine and performance trials.

At 2 g a day TMG is generally well tolerated. Mild digestive upset can occur at higher doses. In trials using 6 g a day, some participants saw a modest rise in blood lipids, which was not seen at lower doses, so if you have high cholesterol, discuss it with your doctor. It is intended for adults. People with kidney conditions, a medical condition or on prescription medication should check with their healthcare professional first. Do not use if pregnant or breastfeeding.

At 3 capsules a day, a bottle lasts 30 days. Two bottles last two months, three last three and five last five. Take more than three a day and it runs out sooner. Each bottle holds 90 vegetable capsules, and the one active ingredient is betaine anhydrous. The capsule is vegetable and the only other ingredient is rice flour, so it suits vegans and vegetarians. Two bottles save 10%, three save 15% and five save 20%.

We dispatch fast from within Australia, to every state and territory. Orders over A$100 ship free. Orders under A$100 have a A$10 standard shipping fee, and express is available for A$13. Metro areas usually receive orders within 3 to 5 business days and regional areas within 5 to 7. Every order is covered by our 30-day money-back guarantee: contact us within 30 days for a full refund. Returns need the original packaging, and return postage within Australia is yours to cover unless the product is faulty.