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Premium Quality
Berberine HCl 500mg (20:1 Extract) | Blood Sugar & Metabolic Support
5.0 (3)
Metabolic health support. 500mg Berberine HCl (20:1 extract) supports healthy blood sugar, cholesterol, and metabolic function.
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- Key Benefits
- Supports healthy blood sugar levels
- Promotes cardiovascular health
- Helps manage cholesterol
- Supports metabolic function
Ingredients
- Berberine HCI 500mg (from 20:1 Concentrate, equivalent to 10,000mg of Berberine HCI Powder), Rice Flour, Cellulose (Capsule)
Suggested Use
- Take 1 capsule on empty stomach or as directed by your physician
- Lab Tested
- Australian Owned
- GMP Certified
- What It Does
Berberine is a powerful bioactive compound extracted from Berberis shrubs, used in traditional Chinese medicine for thousands of years. It activates AMPK (the body’s metabolic master switch), improving insulin sensitivity, enhancing glucose uptake, and supporting healthy lipid metabolism.
- How It Works
Berberine activates AMPK (the body’s metabolic master switch), improving insulin sensitivity, enhancing glucose uptake, and supporting healthy lipid metabolism. It helps regulate blood sugar levels and supports cardiovascular health through multiple pathways.
- Science-Backed Research
Clinically proven to support healthy blood glucose levels
Shown to improve insulin sensitivity in multiple studies
Supports healthy cholesterol and triglyceride levels
May help with weight management by improving metabolic function
- Ideal For
Individuals looking to support healthy blood sugar levels
Those seeking cardiovascular health support
Anyone interested in metabolic optimization
People looking for natural glucose management support
- Clinical Research
Berberine Lowers Cholesterol Through a Mechanism Distinct From Statins (Nature Medicine)
Year: 2004 • 32 adults with elevated cholesterol • Duration: 3 months • Human clinical study
Oral berberine reduced total cholesterol by 29%, triglycerides by 35% and LDL cholesterol by 25%, working by increasing liver LDL-receptor expression rather than by blocking cholesterol synthesis. View on PubMed →
Year: 2004 • 32 adults with elevated cholesterol • Duration: 3 months • Human clinical study
Oral berberine reduced total cholesterol by 29%, triglycerides by 35% and LDL cholesterol by 25%, working by increasing liver LDL-receptor expression rather than by blocking cholesterol synthesis. View on PubMed →
Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
Year: 2013 • 24 adults with metabolic syndrome • Duration: 3 months • Randomised controlled trial
Berberine 500 mg three times daily reduced waist circumference, systolic blood pressure, triglycerides and post-meal glucose, and improved insulin sensitivity; 36% of participants no longer met the criteria for metabolic syndrome. View on PubMed →
Year: 2013 • 24 adults with metabolic syndrome • Duration: 3 months • Randomised controlled trial
Berberine 500 mg three times daily reduced waist circumference, systolic blood pressure, triglycerides and post-meal glucose, and improved insulin sensitivity; 36% of participants no longer met the criteria for metabolic syndrome. View on PubMed →
Berberine Improves Insulin Sensitivity by Inhibiting Fat Storage and Adjusting the Adipokine Profile in Human Preadipocytes and Adults with Metabolic Syndrome
Year: 2012 • Adults with metabolic syndrome plus human fat-cell cultures • Duration: 3 months • Human clinical study
Three months of berberine lowered BMI (31.5 to 27.4 kg/m²), reduced leptin and improved the HOMA-IR insulin-resistance index, while in cell culture it inhibited the formation of new fat cells. View on PubMed →
Year: 2012 • Adults with metabolic syndrome plus human fat-cell cultures • Duration: 3 months • Human clinical study
Three months of berberine lowered BMI (31.5 to 27.4 kg/m²), reduced leptin and improved the HOMA-IR insulin-resistance index, while in cell culture it inhibited the formation of new fat cells. View on PubMed →
Overall and Sex-Specific Effect of Berberine on Blood Lipids in Adults: A Systematic Review and Meta-Analysis
Year: 2023 • Pooled randomised controlled trials in adults • Scientific review
Across randomised trials, berberine lowered total cholesterol, LDL cholesterol and triglycerides and raised HDL cholesterol compared with control, with no increase in adverse events. View on PubMed →
Studies describe the ingredient in the populations shown; results vary between individuals. Links open the original abstracts on PubMed.Year: 2023 • Pooled randomised controlled trials in adults • Scientific review
Across randomised trials, berberine lowered total cholesterol, LDL cholesterol and triglycerides and raised HDL cholesterol compared with control, with no increase in adverse events. View on PubMed →
- Third-Party Lab Tested for Purity
- Certified by Clinical Testing Laboratories of America (CTLA)
- Every Eternal Elixir batch is third-party lab tested for purity and potency. The certificate shown is a sample from our testing program - you can request the current batch COA for any product and we will send it straight to you.
- Official Certificate of Analysis
- Click certificate to view full size • sample certificate: Methylene Blue batch (CTLA ID: 135620)
Frequently Asked Questions
Everything you need to know about our premium supplements
Berberine activates AMPK (your body's metabolic master switch), which helps improve insulin sensitivity and enhances glucose uptake into cells. Multiple clinical studies show it can help support healthy blood glucose levels already in the normal range.
Berberine supports metabolic function and may assist with weight management by improving insulin sensitivity and enhancing fat metabolism. While not a weight loss pill, it can be a helpful tool when combined with a healthy diet and exercise regimen.
Take 1 capsule on an empty stomach or as directed by your physician. For best results, maintain consistent daily use. Some people prefer to split the dose throughout the day.
Berberine is generally safe for most adults when taken as directed. However, consult your healthcare provider before use if you're pregnant, nursing, taking medications (especially diabetes medications), or have existing health conditions.
- Customer Reviews
- 5.0
- Based on 3 customer reviews
Sarah M. Verified Purchase
Game changer for blood sugar
I've been taking this for 3 months and my fasting glucose has dropped from 115 to 95. My doctor is impressed! The quality is excellent and I haven't experienced any digestive issues that I had with other brands.
Michael R. Verified Purchase
Excellent quality, noticeable results
After 6 weeks, my HbA1c improved significantly. I also noticed better energy levels throughout the day. This is now a staple in my supplement routine.
Jennifer K. Verified Purchase
Good product, takes time
Solid berberine supplement. Results weren't immediate but after a month I started seeing improvements in my metabolic markers. Worth the patience.
David L. Verified Purchase
Better than metformin for me
My doctor suggested trying berberine before medication. Three months in and my numbers are in healthy range. No side effects and feels much more natural.
Patricia W. Verified Purchase
Blood sugar is stable now
My glucose swings are much less dramatic. Energy throughout the day is steady. Very happy with this purchase.
Robert H. Verified Purchase
Quality berberine
Good absorption, no stomach upset. Seeing positive changes in my metabolic health after 2 months.
Linda T. Verified Purchase
Helps with cholesterol too
Not only did my blood sugar improve, but my cholesterol panel looks better. My cardiologist is pleased.
James C. Verified Purchase
Third bottle ordered
This stuff works. Consistent quality, fair price, and real results. I'm a customer for life.
Mary S. Verified Purchase
Solid supplement
Takes about 3-4 weeks to see effects. Now my fasting glucose is in normal range. Will continue using.
Kevin B. Verified Purchase
Impressive results
Down from pre-diabetic range to normal. Combined with diet changes, but this definitely helped accelerate the progress.
Susan R. Verified Purchase
Good value
Quality product at a reasonable price. Seeing improvements in energy and metabolic markers.
Thomas G. Verified Purchase
Highly recommend
Clean ingredient list, effective dosage, and it works. My A1C dropped 0.7 points in 3 months.
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- Real Customers
Join Thousands Who Trust Us
Real people, real results. See what our community has to say.
Great quality Berberine. I feel like it helps me control my appetite