Best Supplements for Men Over 40 in Australia 2026: 8 Products Compared for Testosterone, NAD+ & Longevity

Last updated: September 27, 2026 · Originally published: May 13, 2026 · By Eternal Elixir Editorial

Quick answer: For most Australian men over 40, the best supplement to start with is Eternal Elixir Tongkat Ali 200:1 Extract. It is our pick for testosterone support: each three-capsule serving carries 2,000mg of 200:1 root extract, and a 90-capsule bottle costs $39.99, or $1.33 a serving. If longevity matters more to you than drive and training, our pick among the longevity supplements for men is Eternal Elixir NMN 500mg: one 500mg capsule a day, 90 capsules for $59.99, which works out at $0.67 a day. Both ship from Sydney within 24 hours. If the lowest daily cost is all you want, the Swisse Mens Multivitamin 50+ at Chemist Warehouse is $0.44 a day, and Bulk Nutrients sells NMN at $0.66 per 500mg capsule.

Eternal Elixir makes six of the eight products on this page, including the one ranked first, and they are our picks. The other two are the products Australian men most often compare them with: a cheaper NMN from Bulk Nutrients and a men’s multivitamin sold at Chemist Warehouse. Every competitor figure comes from the seller’s own page, read in September 2026. We have not lab-tested any product ourselves. Each study below is described with who took part, how many people, the dose, how long it ran and what changed, and we say plainly where the human evidence is thin.

If you already know which ingredient you want, our single-ingredient comparisons go further: the tongkat ali comparison for Australian buyers, the NMN supplement comparison and the resveratrol comparison.

Best supplements for men over 40 in Australia: the comparison table

All prices are in AUD, as of Sep 2026. Cost per day divides the price by the number of servings the label directs, not by the capsule count. That matters here, because two of our own products use more than one capsule per serving.

Our prices come from our live product pages. Competitor prices were read from the linked pages in September 2026 and change with promotions, so check before you buy. Every Eternal Elixir bottle in this table holds 90 capsules.

Add Tongkat Ali 200:1 to cart · $39.99

Which one should you start with?

You do not need all eight. Pick by the problem you want to work on, then add one product at a time so you can tell what each one is doing.

• Drive, training and testosterone support: Tongkat Ali 200:1 (#1). Several placebo-controlled trials in men have measured its effect on testosterone.
• Cellular energy and NAD+: NMN 500mg (#2). Two placebo-controlled trials in middle-aged and older adults found higher blood NAD+ levels.
• A polyphenol for healthy ageing: Trans-Resveratrol (#3). Read the training caveat in its section first.
• Healthy glucose metabolism: Berberine HCl (#4). Check your medicines before you start it.
• Autophagy, the cell’s recycling process: Spermidine 10mg (#5). A long-game product with early human data.
• The newest idea on the list: Ca-AKG (#6). Strong mouse data, very little in people so far.
• The cheapest NMN per capsule: Bulk Nutrients (#7).
• One tablet of the basics from a pharmacy shelf: Swisse Mens Multivitamin 50+ (#8).

What changes for men after 40, and what supplements can and can’t do

Testosterone falls gradually rather than suddenly. The Massachusetts Male Aging Study enrolled 1,709 men aged 40 to 70 and followed 1,156 of them for seven to ten years. Within the same men, total testosterone fell by about 1.6% a year and bioavailable testosterone by 2% to 3% a year. Men in apparent good health had androgen levels 10% to 15% higher than the rest, which is a reminder that weight, alcohol and general health move these numbers as much as age does.

NAD+, a coenzyme cells use to turn food into energy, also runs lower in older tissue. In skin samples from 49 people aged from newborn to 77, NAD+ levels fell with age in both men and women. That is the reason NAD+ precursors such as NMN are sold for healthy ageing. Measuring higher NAD+ in blood after taking NMN is not the same as showing that people live longer or stay healthier for longer, and no supplement on this page has shown that in humans.

Some things work better than any capsule. Resistance training two to three times a week, enough protein and enough sleep do more for strength and energy after 40 than anything we sell. Google’s summary for this search puts omega-3, vitamin D and creatine at the top of the list, and that is fair. A meta-analysis of 22 trials with 721 participants, mean ages 57 to 70, found that creatine taken during resistance training added 1.37 kg more lean tissue than placebo, along with larger strength gains. We do not sell creatine, fish oil or vitamin D. If your diet has little oily fish, or your GP finds low vitamin D on a blood test, those are sensible places to start before or alongside anything below.

The eight products here sit on top of those basics. They cover four areas that the research on men in their 40s and 50s keeps returning to: hormones, cellular energy, glucose metabolism and the slower processes grouped under “longevity”.

How we ranked these eight supplements

Eternal Elixir makes the products at #1 to #6, so read this before you trust the order. We ranked our own products first on label facts: each of our six bottles holds 90 capsules, the dose per capsule is printed on the label, orders ship from Sydney within 24 hours, and one order can cover several products and clear the $100 free-shipping threshold. Inside our range, tongkat ali and NMN come first because their trials were run in middle-aged and older adults and measured things men over 40 care about: testosterone and NAD+. Ca-AKG, which rests mainly on mouse data, comes last.

The two competitors keep the labels they earn. Bulk Nutrients NMN is cheaper than ours per 500mg capsule. The Swisse multivitamin has the lowest daily cost in the table and is on Chemist Warehouse shelves across the country. Our product pages say every Eternal Elixir batch is third-party lab tested for purity and potency, and that you can ask for the current batch certificate of analysis. We did not test any product ourselves, so testing statements are reported as each seller makes them.

#1. Eternal Elixir Tongkat Ali 200:1 Extract: testosterone and training support

Label facts (Tongkat Ali 200:1 product page): 2,000mg of tongkat ali (Eurycoma longifolia) 200:1 root extract per three-capsule serving, 90 capsules and 30 servings per bottle, $39.99. The label directs three capsules daily on an empty stomach.

Tongkat ali is the root of a South-East Asian shrub, and of the ingredients on this list it is the one most studied for testosterone in men. The results are modest but consistent.

• Men in their 40s: a six-month, double-blind trial in Brazil randomised 45 men with an average age of 47 who had symptoms of age-related androgen decline. Men took 200mg of extract a day or placebo, with or without concurrent training three times a week. The group that combined the extract with training had the clearest results, including a rise in total testosterone (Leitão et al., Maturitas, 2021).
• Active older adults: 13 men and 12 women aged 57 to 72 took 400mg of extract daily for five weeks. Total and free testosterone and handgrip strength all rose. There was no placebo group, so treat this as a pilot (Henkel et al., Phytotherapy Research, 2014).
• Stress hormones: 63 moderately stressed adults (32 men and 31 women) took a standardised hot-water extract or placebo for four weeks. Salivary cortisol exposure was 16% lower and salivary testosterone 37% higher in the tongkat group (Talbott et al., Journal of the International Society of Sports Nutrition, 2013).
• Pooled data: a 2022 review included nine studies and pooled five randomised trials. Total testosterone was higher in men taking the extract than in controls, and the effect held in the subgroup of men who started with low levels (Leisegang et al., Medicina, 2022).

What hasn’t been shown: the trials were small and short, used specific extracts at 200mg to 400mg a day, and several were run with extract makers. Our serving is 2,000mg of a 200:1 extract, much more by weight, but a larger number on the label does not guarantee a larger effect. Extracts differ, and our label does not state a eurycomanone percentage, the marker compound some brands publish. If a stated percentage matters to you, our full tongkat ali comparison lists which brands give one, and our guide to natural testosterone boosters in Australia covers the other herbs men ask about.

Who it suits: men in their 40s and 50s who train and want to support healthy testosterone levels, drive and recovery. At $1.33 a serving it costs more per day than most products here, but three bottles (a 90-day supply) come to $101.97 with the 15% multi-bottle saving, which also ships free.

Who it doesn’t suit: anyone under 18, men using prescribed testosterone, and anyone taking propranolol or other prescription medicines without talking to their doctor first. In 14 healthy young men, a tongkat ali water extract reduced the amount of a single propranolol dose reaching the bloodstream by 29% (Salman et al., 2010).

Add Tongkat Ali 200:1 to cart · $39.99

#2. Eternal Elixir NMN 500mg: NAD+ and cellular energy

Label facts (NMN 500mg product page): 500mg nicotinamide mononucleotide (NMN) per capsule, 90 capsules per bottle, one capsule daily, preferably in the morning. $59.99, or $0.67 a day, and one bottle lasts three months.

NMN is a building block the body turns into NAD+. The human trials in this age group are small, but they are placebo-controlled:

• Middle-aged adults: 80 healthy adults took placebo or 300mg, 600mg or 900mg of NMN once a day for 60 days. Blood NAD+ rose in every NMN group, with the highest levels at 600mg and 900mg. Six-minute walking distance improved more than with placebo, and self-rated health scores rose. Insulin resistance scores did not change. Three of the authors declared employment with the companies Abinopharm and ABA Chemicals (Yi et al., GeroScience, 2023).
• Men aged 65 and over: 42 healthy men took 250mg of NMN or placebo daily for up to 12 weeks. Blood NAD+ and related metabolites rose, and there were small improvements in gait speed and grip strength that the authors say need confirming in larger studies. Body composition did not change. A supply error at six weeks meant only 20 men completed the full 12 weeks (Igarashi et al., npj Aging, 2022).

What hasn’t been shown: any effect on lifespan in people, and any benefit beyond a few months. The longevity results you may have read about come from mice. One of our capsules gives 500mg, between the 300mg and 600mg arms of the larger trial.

Who it suits: men over 40 building a longevity routine who want one capsule a day and a three-month bottle. It is the product we would add second, after tongkat ali, or first if energy and ageing interest you more than hormones.

Who it doesn’t suit: anyone who wants the lowest possible cost per capsule. Bulk Nutrients (#7) is slightly cheaper. It also isn’t for anyone pregnant or breastfeeding, and you should talk to your doctor first if you take prescription medicines. Our NAD+ supplement comparison sets NMN against NR and other precursors.

#3. Eternal Elixir Trans-Resveratrol 1200mg: a polyphenol for healthy ageing

Label facts (Trans-Resveratrol product page): 600mg trans-resveratrol per capsule, two capsules (1,200mg) per serving, 90 capsules and 45 servings per bottle. $59.99, or $1.33 a serving. The label says two capsules daily, with or without food.

Resveratrol is the polyphenol found in grape skins. It became popular as a partner for NMN, but the human results pull in two directions, and men who train hard should read both:

• For it: 46 healthy, overweight older adults took 200mg a day or placebo for 26 weeks in Germany. The resveratrol group remembered more words after 30 minutes, and their HbA1c (a three-month blood glucose average) and body fat fell compared with placebo (Witte et al., Journal of Neuroscience, 2014).
• Against it, if you train: 27 inactive men aged about 65 did eight weeks of high-intensity training while taking 250mg of trans-resveratrol or placebo. The placebo group’s gain in maximal oxygen uptake was 45% greater, and only the placebo group’s blood pressure fell. Resveratrol also cancelled the training-related improvements in blood fats (Gliemann et al., Journal of Physiology, 2013).

What hasn’t been shown: any trial at our 1,200mg serving in men over months, and any evidence on whether taking resveratrol away from training days changes the result above. Both trials used far less than our serving.

Who it suits: men over 40 who want a polyphenol in their routine and whose main goal is not fitness gains from hard training.

Who it doesn’t suit: men in a serious training block who care most about fitness results, given the Gliemann finding. Talk to your doctor or pharmacist first if you take blood-thinning or other prescription medicines. Our resveratrol comparison covers dose, form and price across Australian brands.

#4. Eternal Elixir Berberine HCl 500mg: healthy glucose metabolism

Label facts (Berberine HCl product page): 500mg berberine HCl per capsule as a 20:1 extract, which the label describes as equivalent to 10,000mg of starting material. 90 capsules, one capsule a serving on an empty stomach, $49.99 or $0.56 a day.

Berberine is a yellow plant alkaloid found in barberry and several other herbs. It is one of the most studied botanicals for glucose and blood fat metabolism, but the trials need reading carefully. A meta-analysis of 27 randomised trials with 2,569 participants found berberine, alongside lifestyle changes, lowered blood glucose and blood fat markers more than lifestyle changes alone. Almost all of those participants already had readings above the healthy range, and the authors rated the study quality as limited (Lan et al., Journal of Ethnopharmacology, 2015). So these trials tell you little about what berberine does in a healthy man whose numbers are normal.

What we can say is that berberine may help maintain healthy glucose metabolism as part of a diet and exercise routine. What hasn’t been shown: any long-term benefit in healthy men, or any effect on lifespan.

Who it suits: men over 40 who want to support healthy glucose metabolism alongside diet and training, and who have checked their medicines with a pharmacist.

Who it doesn’t suit: anyone on prescription medicines who has not asked their doctor or pharmacist first. In 18 healthy young men, berberine at 300mg three times a day for 14 days slowed three liver enzymes (CYP2D6, CYP2C9 and CYP3A4) that clear many common medicines (Guo et al., European Journal of Clinical Pharmacology, 2012). Anyone taking medicine to lower blood glucose should not start berberine without medical advice, and it is not for use in pregnancy or breastfeeding.

Add Berberine HCl 500mg to cart · $49.99

#5. Eternal Elixir Spermidine 10mg: autophagy research

Label facts (Spermidine 10mg product page): 10mg spermidine (as spermidine trihydrochloride) per capsule, 90 capsules per bottle, one capsule daily with a meal. $49.99, or $0.56 a day.

Spermidine is a polyamine found naturally in food, and supplement forms are often extracted from wheat germ. Its reputation comes from autophagy, the process cells use to break down and recycle worn-out parts. Here the evidence splits sharply by species:

• Mice: oral spermidine extended lifespan and kept older mouse hearts working better (Eisenberg et al., Nature Medicine, 2016). This is an animal result and cannot be carried over to men.
• Diet studies in people: in 829 adults aged 45 to 84 followed for about 20 years, those with the highest spermidine intake from food had lower death rates (Kiechl et al., American Journal of Clinical Nutrition, 2018). This is observational. People who eat more spermidine-rich food may differ in many other ways.
• A capsule trial: 100 adults aged 60 to 90 who felt their memory was slipping took 0.9mg a day of wheat-germ spermidine or placebo for 12 months. Memory scores did not differ from placebo (Schwarz et al., JAMA Network Open, 2022).

What hasn’t been shown: any benefit from spermidine capsules in a controlled human trial so far. Our capsule’s 10mg is a much larger amount than that trial used. The two figures are not directly comparable because ours is stated as a salt, and no trial has yet tested a 10mg capsule over years.

Who it suits: men already taking NMN who want to add a second longevity product with a long horizon. It is also sold with NMN and trans-pterostilbene in our Cellular Longevity Stack ($139.99), so buy one or the other, not both.

Who it doesn’t suit: men looking for something they will notice within weeks. People with a wheat allergy should check with their doctor. If you were hoping to pick it up at Chemist Warehouse, see the buying section below: in September 2026 its site did not list a spermidine supplement. Our spermidine supplement comparison lists where you can buy it in Australia.

#6. Eternal Elixir Ca-AKG 500mg: the newest idea on the list

Label facts (Ca-AKG product page): 500mg calcium alpha-ketoglutarate (Ca-AKG) per capsule, 90 capsules and 90 servings per bottle, one capsule daily. $59.99, or $0.67 a day.

Alpha-ketoglutarate is a normal product of the energy cycle inside every cell, and its levels change with fasting, exercise and age. The interest comes from animal work:

• Mice: mice fed Ca-AKG lived longer, spent less of their life frail and had lower levels of inflammatory markers (Asadi Shahmirzadi et al., Cell Metabolism, 2020). This is a mouse result.
• People: a retrospective analysis of 42 people who took a commercial Ca-AKG and vitamin formula for about seven months found an average drop of 8 years in a DNA methylation age test. There was no placebo group, the formula contained other ingredients, and one author consulted for the maker (Demidenko et al., Aging, 2021).

What hasn’t been shown: any result from a placebo-controlled human trial. We rank it last of our six for that reason.

Who it suits: men who already take NMN and want to add an early-stage longevity compound, knowing the human data is thin. Our mitochondrial support comparison sets it against other cellular energy products.

Who it doesn’t suit: anyone who wants proof in people before they spend money. Talk to your doctor first if you take calcium supplements or prescription medicines.

#7. Bulk Nutrients NMN Capsules: lowest cost per 500mg of NMN

Label facts (from the Bulk Nutrients product page, Sep 2026): 500mg NMN per capsule, 120 capsules for $79.00. Directions are one to two capsules daily, with or without food. Four tubs drop the price to $67.00 each, and shipping is a flat $9 Australia-wide.

Bulk Nutrients is an Australian online supplement store that also sells protein powders. Its NMN is a straightforward single-ingredient capsule with the same 500mg per capsule as ours, and the page links certificates of analysis. At one capsule a day it costs $0.66, a cent under ours, and the four-tub price takes it to $0.56 a capsule. The page showed a rating of 4.64 from 136 reviews when we checked.

Who it suits: buyers who want the lowest NMN cost per capsule, or who already order protein from Bulk Nutrients and want one delivery.

Who it doesn’t suit: men who want NMN alongside tongkat ali, spermidine or other longevity products in one order. The flat $9 shipping fee applies to each Bulk Nutrients order, while our orders over $100 ship free.

#8. Swisse Mens Multivitamin 50+: lowest daily cost, on pharmacy shelves

Label facts (from the Chemist Warehouse listing, Sep 2026): 60 tablets for $26.49 (RRP $52.99), one tablet daily with a meal. Each tablet lists 25µg (1000 IU) of vitamin D3, 15mg zinc, 105mg magnesium, 50µg selenium, 50µg vitamin B12 and 3mg coenzyme Q10, plus small amounts of saw palmetto, ginkgo, milk thistle and turmeric extracts. It contains soy.

This is the product for a man who wants one daily tablet covering the basic vitamins and minerals and can pick it up at any Chemist Warehouse. At $0.44 a day it is the cheapest daily option in the table. It is not a longevity product in the sense the other seven are. It contains no NMN, tongkat ali, berberine or spermidine.

Who it suits: men over 50 who want a single everyday tablet and prefer to buy in store.

Who it doesn’t suit: men who already take a separate zinc or selenium supplement. The label warns that adults should not exceed 150µg of selenium a day from supplements. It is also not for anyone looking for the specific ingredients studied for testosterone or NAD+.

Building a men-over-40 routine: what it costs per day

A focused routine does more than a cupboard full of bottles. Start with one product for four to eight weeks before you add the next, so you can judge each one on its own. These daily costs use single-bottle prices, as of Sep 2026:

• Start: Tongkat Ali 200:1, three capsules each morning. $1.33 a day.
• Add cellular energy: NMN 500mg, one capsule each morning. $2.00 a day for both.
• Add glucose support (if relevant to you): Berberine HCl, one capsule a day. $2.56 a day for all three.
• Add the longevity extras: Spermidine 10mg and Ca-AKG 500mg, one capsule of each. $3.79 a day for all five.

Resveratrol is an optional extra at $1.33 a serving. Leave it out during hard training blocks if fitness gains are your priority. Buying two bottles of any product saves 10%, three save 15% and five save 20%. Orders over $100 ship free, and Afterpay is available.

If you prefer a ready-made set, our Cellular Longevity Stack combines NMN, spermidine and trans-pterostilbene for $139.99. For men who want an energy-focused routine instead, the Daily Energy & Vitality Stack ($109.99) combines Tongkat Ali, shilajit and Korean red ginseng. Our longevity supplement stack comparison goes through five stack tiers in detail.

Safety: who should check with a doctor first

These are the cautions that matter most for men over 40. They are not a full list, so read each label as well.

• Prescription medicines: berberine slows liver enzymes that clear many medicines, and tongkat ali reduced propranolol absorption in a small study. If you take any prescription medicine, ask your doctor or pharmacist before you start either.
• Blood thinners: talk to your doctor before taking resveratrol if you use blood-thinning medicine.
• Hormone therapy: do not add tongkat ali to prescribed testosterone without medical advice.
• Blood glucose medicine: berberine is studied for its effect on blood glucose, so do not combine it with glucose-lowering medicine without your doctor’s advice.
• Serotonergic medicines: methylene blue is not suitable if you take them.

A baseline blood test is the most useful step you can take before starting. Ask your GP about total and free testosterone, SHBG, fasting glucose and HbA1c, a lipid panel, vitamin D, B12, ferritin, and liver and kidney function. Repeat it after about 90 days, which is one bottle of most of our range, and you have a clear before and after to judge by.

Where to buy these supplements in Australia, including Chemist Warehouse

Chemist Warehouse is where most Australian men start looking, and it now stocks some longevity products. It sells NMN from several brands, including Bioglan NMN 500 at $42.49 for 30 capsules of 500mg when we checked in September 2026. It also carries multivitamins such as the Swisse product above and several berberine brands.

Three of our products were missing from its range. A search of chemistwarehouse.com.au in September 2026 returned no spermidine supplement (the only result for “spermidine” was a skin serum), no tongkat ali capsules (the only results were two protein powders) and no Ca-AKG supplement. For those, you need a specialist online store. We ship from Sydney within 24 hours, with free shipping on orders over $100 and a 30-day money-back guarantee. For more on how we compare with other local brands, see our Eternal Elixir review.

Frequently asked questions

What are the best longevity supplements for men?

Our pick is Eternal Elixir NMN 500mg for longevity and Eternal Elixir Tongkat Ali 200:1 Extract for testosterone support. NMN raised blood NAD+ in placebo-controlled trials in middle-aged adults and in men over 65, and one capsule a day costs $0.67. Remember that no supplement has been shown to extend human lifespan. Training, sleep and protein come first.

Add NMN 500mg to cart · $59.99

What is the best supplement for men over 40 in Australia?

For most men over 40, our pick is Eternal Elixir Tongkat Ali 200:1 Extract: 2,000mg of 200:1 root extract per three-capsule serving, 90 capsules for $39.99, shipped from Sydney. Tongkat ali has been tested for testosterone in men in several placebo-controlled trials, including a six-month trial in men averaging 47. If you want the lowest daily cost instead, the Swisse Mens Multivitamin 50+ is $0.44 a day.

Add Tongkat Ali 200:1 to cart · $39.99

What are the top 3 supplements for men?

From our range, the three we would start with are tongkat ali for testosterone support, NMN for NAD+ and spermidine as a longer-term longevity product. Outside our range, creatine taken with resistance training has good evidence for strength and lean mass in older adults from a meta-analysis of 22 trials, and vitamin D is worth taking if a blood test shows yours is low.

What are the top 3 supplements for longevity?

The three most discussed options are NAD+ precursors such as NMN, spermidine and resveratrol, though none has been shown to extend human lifespan. NMN has the clearest human data, with higher blood NAD+ in two placebo-controlled trials. Spermidine is linked to lower death rates in a diet study but not yet in a capsule trial. Resveratrol results are mixed, and one trial found it blunted training gains in older men.

What are the best longevity supplements available in Australia?

Our pick is Eternal Elixir NMN 500mg, with spermidine and Ca-AKG from the same range for men who want to go further. All three come in 90-capsule bottles and ship from Sydney. Chemist Warehouse stocks NMN, but in September 2026 its site did not list spermidine or Ca-AKG supplements.

Can you buy a spermidine supplement at Chemist Warehouse?

Not when we checked. In September 2026 a search for “spermidine” on chemistwarehouse.com.au returned one result, a skin serum, and no spermidine supplement. You can buy spermidine online from specialist stores, including our Spermidine 10mg: 90 capsules for $49.99, one a day with a meal.

Add Spermidine 10mg to cart · $49.99

Is tongkat ali legal in Australia?

Yes. Tongkat ali capsules are sold openly by Australian supplement stores, including the retailers in our tongkat ali comparison, and they ship within Australia. Buy from a seller that prints the extract ratio and the amount per serving on the label, so you know what you are taking.

What dose of NMN should a man over 40 take?

Follow the label. Our NMN label directs one 500mg capsule a day. In the largest dose trial, 80 middle-aged adults took 300mg, 600mg or 900mg a day for 60 days, and blood NAD+ was highest at 600mg and 900mg. A trial in men over 65 used 250mg a day. Nobody has tested which dose works best over years.

Can I take berberine and NMN together?

We found no published trial that tested the two together. Berberine is best taken as its label directs, and NMN is usually taken in the morning. The bigger question with berberine is your other medicines, because it slows enzymes that clear many prescription drugs. Ask your pharmacist first if you take any.

Should men over 40 cycle these supplements or take them continuously?

There is no trial evidence that cycling improves results for any product on this page. The tongkat ali trials above ran daily for four weeks to six months, and the NMN trials ran daily for 60 days and 12 weeks. Some men take breaks from tongkat ali by preference. Keep to the label dose, and stop and get advice if anything feels wrong.

How much does a men’s over-40 supplement routine cost in Australia?

Tongkat ali alone is $1.33 a day. Adding NMN brings it to $2.00 a day, and a five-product routine with berberine, spermidine and Ca-AKG comes to $3.79 a day at single-bottle prices. Multi-bottle savings of 10% to 20% reduce that, and orders over $100 ship free.

Is supplementation enough, or do I need lifestyle changes too?

You need the lifestyle changes. Resistance training, enough protein and seven to nine hours of sleep make a bigger difference to strength, energy and body composition after 40 than any supplement. In the creatine meta-analysis above, every trial combined the supplement with resistance training. In the tongkat ali trial in men in their 40s, the best result came with training.

The verdict: which supplement should you buy first?

Our pick for most men over 40: Eternal Elixir Tongkat Ali 200:1 Extract. It has been tested for testosterone in several placebo-controlled trials in men, carries 2,000mg of 200:1 extract per serving and costs $39.99 for 90 capsules, shipped from Sydney within 24 hours. Give it at least eight weeks at the label dose before you judge it.

Our pick if longevity is the goal: Eternal Elixir NMN 500mg, one capsule a day at $0.67. Add it second if you started with tongkat ali.

If the lowest cost per capsule of NMN decides it: Bulk Nutrients NMN at $0.66 a capsule, or less if you buy four tubs.

If you want one everyday tablet from a pharmacy: Swisse Mens Multivitamin 50+ at $0.44 a day.

Whichever you choose, get a baseline blood test, add one product at a time and check the safety section if you take prescription medicines.

More guides: anti-ageing supplements compared, energy supplements for fatigue and brain fog, Korean red ginseng compared and, for partners, supplements for women over 40. You can also browse all our supplement guides, the Eternal Elixir blog or the full Eternal Elixir range.

Sources

• Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2002;87(2):589-98. PubMed 11836290
• Massudi H, Grant R, Braidy N, et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7(7):e42357. PubMed 22848760
• Chilibeck PD, Kaviani M, Candow DG, Zello GA. Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis. Open Access J Sports Med. 2017;8:213-226. PubMed 29138605
• Leitão AE, Vieira MCS, Pelegrini A, da Silva EL, Guimarães ACA. A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM). Maturitas. 2021;145:78-85. PubMed 33541567
• Henkel RR, Wang R, Bassett SH, et al. Tongkat Ali as a potential herbal supplement for physically active male and female seniors: a pilot study. Phytother Res. 2014;28(4):544-50. PubMed 23754792
• Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013;10(1):28. PubMed 23705671
• Leisegang K, Finelli R, Sikka SC, Panner Selvam MK. Eurycoma longifolia (Jack) improves serum total testosterone in men: a systematic review and meta-analysis of clinical trials. Medicina (Kaunas). 2022;58(8):1047. PubMed 36013514
• Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol’s bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther. 2010;35(6):691-6. PubMed 21054461
• Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43. PubMed 36482258
• Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022;8(1):5. PubMed 35927255
• Witte AV, Kerti L, Margulies DS, Flöel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci. 2014;34(23):7862-70. PubMed 24899709
• Gliemann L, Schmidt JF, Olesen J, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol. 2013;591(20):5047-59. PubMed 23878368
• Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed 25498346
• Guo Y, Chen Y, Tan ZR, Klaassen CD, Zhou HH. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol. 2012;68(2):213-7. PubMed 21870106
• Eisenberg T, Abdellatif M, Schroeder S, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428-1438. PubMed 27841876
• Kiechl S, Pechlaner R, Willeit P, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018;108(2):371-380. PubMed 29955838
• Schwarz C, Benson GS, Horn N, et al. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical trial. JAMA Netw Open. 2022;5(5):e2213875. PubMed 35616942
• Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metab. 2020;32(3):447-456.e6. PubMed 32877690
• Demidenko O, Barardo D, Budovskii V, et al. Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021;13(22):24485-24499. PubMed 34847066
• Bulk Nutrients NMN Capsules product page, read September 2026. bulknutrients.com.au
• Swisse Mens Multivitamin 50+ 60 tablets, Chemist Warehouse listing, read September 2026. chemistwarehouse.com.au
• Bioglan NMN 500 30 capsules, Chemist Warehouse listing, read September 2026. chemistwarehouse.com.au
• Eternal Elixir product pages and labels for Tongkat Ali 200:1, NMN 500mg, Trans-Resveratrol 1200mg, Berberine HCl 500mg, Spermidine 10mg and Ca-AKG 500mg. eternalelixir.com.au