TMG 2000mg | Trimethylglycine for Methylation & Liver Support

When NAD+ is used, it releases nicotinamide, which the body clears by attaching a methyl group to it through the enzyme NNMT. Raising NAD+ with NMN or NR therefore increases the demand on your methyl reserves. TMG replenishes those reserves and keeps homocysteine in check. Whether every NMN user strictly needs it is still debated in the research, but it is inexpensive insurance, and the homocysteine benefit stands on its own. Take it with your morning NMN.

TMG donates a methyl group directly to homocysteine through the liver enzyme BHMT, converting it back into methionine. In a six-week randomised trial of healthy adults, 1.5 g and 3 g of betaine a day lowered fasting homocysteine by 12% and 15% respectively, and blunted the homocysteine spike after a methionine-rich meal by up to 40%. Our 2,000 mg serve sits inside that range. Because it works through a different pathway from folate and B12, it complements rather than replaces them.

Take three capsules a day, which gives 2,000 mg of betaine anhydrous. This matches the 1.5–3 g range used in the homocysteine trials and the 2.5 g used in the exercise study. Higher doses (6 g) have been studied, but 2 g is where most of the benefit appears; if you are targeting a specific homocysteine result, work with your doctor and retest after six to eight weeks.

With a meal. Most people take all three capsules at breakfast alongside NMN or NR, because that is when the extra methyl demand arrives. Splitting the serve across two meals is fine too; consistency matters more than timing. In the trials, the homocysteine-lowering effect was measurable from the first day and stable by week two.

Betaine is concentrated in the liver, where it does two jobs: it acts as an osmolyte that helps liver cells manage water balance under stress, and it supplies the methyl groups the liver needs to package and export fat as VLDL rather than store it. That is why it is studied for liver health and healthy fat metabolism. For liver support, it pairs well with our TUDCA.

No. Betaine HCl is a hydrochloride salt sold as a digestive aid to increase stomach acid, and it is not the right form for methylation. Betaine anhydrous, the pure trimethylglycine in this product, is the form used in every homocysteine and performance trial. Check the label of any TMG product for the word anhydrous.

At 2 g a day TMG is generally well tolerated; mild digestive upset can occur at higher doses. In trials using 6 g a day, some participants saw a modest rise in blood lipids, which was not seen at lower doses, so if you have elevated cholesterol discuss it with your doctor. It is intended for adults, and people with kidney conditions, a medical condition or on prescription medication should check with their healthcare professional first. Do not use if pregnant or breastfeeding.

Each bottle contains 90 vegetable capsules. At three capsules a day that is 30 servings, a full 30-day supply. The only ingredients are betaine anhydrous, a vegetable capsule and rice flour, so it is suitable for vegans and vegetarians. Choose two bottles to save 10%, three to save 15% or five to save 20%.

Yes on both counts. Every batch is independently tested by an accredited third-party laboratory for identity, potency and purity, including heavy metals and microbial contaminants, and a current certificate of analysis is available on request. We ship to every Australian state and territory from our Australian warehouse; orders over $100 ship free, orders are dispatched within 24 hours on business days, and every order is covered by our 30-day money-back guarantee.